方法：通过原代和传代培养，获得性状稳定的人牙周膜细胞，使用动态机械应变细胞加载仪对细胞进行1%、10%和20%动态牵张应变加载。
METHODS: Primary human periodontal ligament cells were obtained and passaged. Then the cells were stretched by dynamic mechanical strain unit with 1%, 10% and 20% strain at different time.
结果：加载模拟咬合压力的人牙周膜成纤维细胞COX 2表达水平明显高于对照组，而且在一定范围内表达水平与加压力值成剂量依赖关系；
Res ults: COX-2 expression level in HPLFs loaded with intermittent simulated occlusion pressure was significantly higher than that in the controls in a magnitude-dependent manner.
结果：加载模拟咬合压力的人牙周膜成纤维细胞COX 2表达水平明显高于对照组，而且在一定范围内表达水平与加压力值成剂量依赖关系；
Res ults: COX-2 expression level in HPLFs loaded with intermittent simulated occlusion pressure was significantly higher than that in the controls in a magnitude-dependent manner.
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