依赖于半胱氨酸蛋白酶的激活，美沙酮通过激活线粒体克服了白血病细胞中的阿霉素耐药、多药耐药、和凋亡抑制。
Depending on caspase activation, methadone overcomes doxorubicin resistance, multidrug resistance, and apoptosis resistance in leukemia cells through activation of mitochondria.
目的多药耐药性是导致急性白血病化疗失败的主要原因。
Objective Multidrug resistance can eventually result in the chemotherapy failure of acute leukemia.
目的研究多药耐药(MDR- 1)基因在急性白血病(AL)治疗中的表达。
Objective To study on the expression of multiple drug resistance (MDR 1) gene during treatment course of acute leukemia (AL).
目的通过检测儿童急性白血病多药耐药基因及细胞凋亡调控基因表达水平的改变，分析不同类型白血病的主要耐药机制。
Objective To study the drug resistance in different types of acute leukemia in children, the expression of multidrug resistance gene and apoptosis-related genes were analyzed.
该技术为白血病多药耐药的基础和临床研究开辟了新思路，也为新的分子诊断和分子治疗提供可能。
It is a new way for the study of multidrug resistance of leukemia. RNAi may be a new research tool of molecular diagnosis and molecular therapy on leukemia in the future.
目的探讨CYP3A5基因与白血病细胞多药耐药的关系。
Objective To investigate if CYP3A5 gene is involved in the molecular mechanisms for multiple drug resistance in leukemia cells.
结论FFJZ可能成为治疗白血病多药耐药安全有效的逆转药物。
Conclusion FFJZ may become a safe and effective multidrug resistance-reversing agent with low toxicity in leukemia chemotherapy.
结论FFJZ可能成为治疗白血病多药耐药安全有效的逆转药物。
Conclusion FFJZ may become a safe and effective multidrug resistance-reversing agent with low toxicity in leukemia chemotherapy.
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