目的：研究血竭对大鼠背根神经节细胞电压门控性钠通道电流的影响。
Objective: to investigate the effects of blood resin on voltage gated sodium channel current in freshly isolated rat DRG neurons.
结果：血竭剂量依赖地抑制单个DRG细胞电压门控性钠通道电流，高剂量的血竭抑制作用不可逆。
The inhibition effect was irreversible at high dosage. Conclusion: blood resin inhibits the voltage gated sodium channel currents, which may well provide some analgesic effects.
结论野木瓜注射液除影响髓鞘和轴突膜结构外还通过调制初级感觉神经元电压门控性钠通道，影响痛觉信息中枢传入产生镇痛作用。
Conclusion The analgesic effect of IS was presumably caused by modulation of voltage-gated sodium channels in primary sensory neurons besides structure destruction of myelin sheath and axon membrane.
结论野木瓜注射液除影响髓鞘和轴突膜结构外还通过调制初级感觉神经元电压门控性钠通道，影响痛觉信息中枢传入产生镇痛作用。
Conclusion The analgesic effect of IS was presumably caused by modulation of voltage-gated sodium channels in primary sensory neurons besides structure destruction of myelin sheath and axon membrane.
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