目的：研究血竭对大鼠背根神经节细胞电压门控性钠通道电流的影响。
Objective: to investigate the effects of blood resin on voltage gated sodium channel current in freshly isolated rat DRG neurons.
结论野木瓜注射液除影响髓鞘和轴突膜结构外还通过调制初级感觉神经元电压门控性钠通道，影响痛觉信息中枢传入产生镇痛作用。
Conclusion The analgesic effect of IS was presumably caused by modulation of voltage-gated sodium channels in primary sensory neurons besides structure destruction of myelin sheath and axon membrane.
方法：在去除滤泡膜的非洲爪蟾卵母细胞上，建立双电极电压钳记录技术，并使用该技术观察爪蟾卵母细胞表达的内源性递质门控性和电压门控性离子通道电流。
Methods: the two-electrode voltage clamp recording technique was used to observe the ligand-gated and voltage-gated ion channel currents expressed in Xenopus laevis oocytes without follicles.
结果表明， 在采集电压门控性离子通道电流时，合理地利用P/N漏减会使离子电流记录更为准确可靠。
Our results indicate that voltage-gated ion channel currents recorded by Clampex will be more accurate and reproducible by properly using P/N leak subtraction.
结果：血竭剂量依赖地抑制单个DRG细胞电压门控性钠通道电流，高剂量的血竭抑制作用不可逆。
The inhibition effect was irreversible at high dosage. Conclusion: blood resin inhibits the voltage gated sodium channel currents, which may well provide some analgesic effects.
结果：血竭剂量依赖地抑制单个DRG细胞电压门控性钠通道电流，高剂量的血竭抑制作用不可逆。
The inhibition effect was irreversible at high dosage. Conclusion: blood resin inhibits the voltage gated sodium channel currents, which may well provide some analgesic effects.
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