过去甲基化的结构研究被阻碍的原因是因为很难制备组蛋白特定部位赖氨酸甲基化的均一样品。
Past structural studies of methylation were hindered by the extreme difficulty of constructing homogeneous samples of histones bearing methyl groups attached to specific lysine residues.
组蛋白赖氨酸甲基化是组蛋白尾段发生的一种重要共价修饰，在基因的表观遗传转录调控中起着关键的作用。
The methylation of histone lysine is an important covalent modification at its tails and plays a key role in epigenetic regulation.
组蛋白H3第27位赖氨酸的甲基化与同源盒基因沉默、X染色体失活、基因印记等基因沉默现象有关；
The methylation of histone H3-K27 was proved to be linked to several silencing phenomena including homeotic-gene silencing, X inactivation and genomic imprinting.
但是Shokat和他的同事已经在实验室合成了一种化学物质，它的结构可以模拟甲基化的赖氨酸。
However, Shokat and his colleagues had synthesized a chemical structure in the lab that mimics lysine with the methyl groups attached.
组蛋白赖氨酸甲基化在基因表达调控中的作用已成为表观遗传学研究的热点。
The role of histone lysine methylation in the gene expression regulation has turned into the hotspot of epigenetics.
组蛋白赖氨酸的甲基化在真核基因表观遗传调控中起着关键作用。
Histone lysine methylation plays a key role in epigenetic regulation of eukaryotic genes.
随着组蛋白赖氨酸去甲基化酶的发现，证实组蛋白赖氨酸甲基化是一个可以逆转的组蛋白表遗传修饰。
The discovery of the histone lysine demethylases has strongly demonstrated that histone lysine methylation is a reversible epigenetic modification.
抑制性标记由3个甲基基团组成，结合到组蛋白H4的一个赖氨酸残基上。
The repressive mark was composed of three methyl groups attached to a lysine on the H4 histone.
组蛋白赖氨酸去甲基化酶有可能成为一个新的抗肿瘤治疗靶标。
Therefore, histone lysine demethylases may serve as a new target for anti-cancer therapy.
赖氨酸甲基化是组蛋白共价修饰之一，在多种生物学过程有重要作用。
One such modification, lysine methylation, has important functions in many biological processes.
赖氨酸甲基化是组蛋白共价修饰之一，在多种生物学过程有重要作用。
One such modification, lysine methylation, has important functions in many biological processes.
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