第一部分：3 -酮基- 6 - O -甲基红霉素- 9 -取代肟基衍生物的合成与体外抗菌活性。

The first part: synthesis and in vitro activity of 3-keto-9-o-substituted oxime derivatives of 6-o-methyl erythromycin a.

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红霉素碱经肟化、保护再经甲基化、脱保护得到克拉霉素，总收率达40 %以上。

Clarithromycin was prepared from erythromycin a through oximation, protection, methylation and deprotection. The overall yield of clarithromycin was 40%.

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同时肝微粒体蛋白含量、CYP450含量和红霉素-N-脱甲基酶活性呈现有一定的性别差异。

And the liver microsome protein content, CYP450 content and erythromycin-N-demethylase activity appear some gender differences.

youdao

同时肝微粒体蛋白含量、CYP450含量和红霉素-N-脱甲基酶活性呈现有一定的性别差异。

And the liver microsome protein content, CYP450 content and erythromycin-N-demethylase activity appear some gender differences.

youdao