与之相反，L -甲硫氨酸增加了甲基化水平，从而减弱了正常老鼠中糖皮质激素受体基因的表达，导致了恐惧、焦虑和对压力的强烈反应。
By contrast, L-methionine increased the level of methylation and thus reduced the expression of the gene in animals with loving mothers, and led to fear, anxiety and a heightened response to stress.
过去甲基化的结构研究被阻碍的原因是因为很难制备组蛋白特定部位赖氨酸甲基化的均一样品。
Past structural studies of methylation were hindered by the extreme difficulty of constructing homogeneous samples of histones bearing methyl groups attached to specific lysine residues.
组蛋白H3第27位赖氨酸的甲基化与同源盒基因沉默、X染色体失活、基因印记等基因沉默现象有关；
The methylation of histone H3-K27 was proved to be linked to several silencing phenomena including homeotic-gene silencing, X inactivation and genomic imprinting.
目的：研究一氧化氮合酶抑制剂N-硝基-L-精氨酸甲基酯对大鼠肠系膜淋巴管作用。
Objective: To study the effect of NG-nitro-L-arginine methyl ester, one of the inhibitors of NOS, on rats' mesenteric lymphatic vessels.
目的研究大鼠脑局灶性缺血再灌注模型中N甲基D天冬氨酸（NMDA）受体随时间的变化。
Objective To study the changes of N methyl D aspartate(NMDA) receptor in the rat brain during reperfusion after local ischemia.
这些物质加上叶酸，维生素b - 12和蛋氨酸都是甲基供体。
These substances plus Folic acid, Vitamin B-12 and SAMe are all methyl donors.
甜菜碱的甲基化有利于转换同型半胱氨酸为氨基酸蛋氨酸。
Methylation with TMG helps to convert the undesirable chemical homocysteine into the amino acid methionine.
组蛋白赖氨酸甲基化在基因表达调控中的作用已成为表观遗传学研究的热点。
The role of histone lysine methylation in the gene expression regulation has turned into the hotspot of epigenetics.
总结了组蛋白精氨酸甲基化修饰体系的最新研究进展。
Here, the most recent progresses in the methylation studies of histone arginine were summa.
目的探讨兴奋性氨基酸受体拮抗剂磷酸甲基谷氨酰氨酸（GAPA）对胆红素神经毒性的影响。
Objective To explore the effect of NMDA receptor antagonist glutamyl amino methyl phosphonic acid (GAPA) on the bilirubin neurotoxicity.
甲基基团（CH3）附着在SAM中蛋氨酸硫原子具有化学反应性。
The methyl group (CH3) attached to the methionine sulfur atom in SAM is chemically reactive.
目的研究虎杖苷(PD)与非对称性二甲基精氨酸(adma)对正常兔主动脉血管条内皮功能的影响及PD与adma之间的相互作用。
ObjectTo study the effect of polydatin (PD) and asymmetric dimethylarginine (ADMA) on the endothelial function in aorta vascular strips of healthy rabbits and the interaction between PD and ADMA.
组蛋白赖氨酸的甲基化在真核基因表观遗传调控中起着关键作用。
Histone lysine methylation plays a key role in epigenetic regulation of eukaryotic genes.
目的：研究N甲基D天冬氨酸（NMDA）诱导大鼠小脑颗粒神经元兴奋毒性保护作用的机制。
Objective:To study the mechanisms underlying N methyl D aspartate (NMDA) induced excitoprotection in cultured rat cerebellar granule neurons.
方法健康清洁级大鼠24只，随机分为3组：二甲基乙二酰基甘氨酸（TMOG）组、对照组、假手术组，每组8只。
Methods 24 rats of clean grade were randomly divided into 3 groups: acyl ethylene dimethyl glycine (TMOG) group and the control group, sham-operated group, 8 in each group.
组蛋白赖氨酸甲基化是组蛋白尾段发生的一种重要共价修饰，在基因的表观遗传转录调控中起着关键的作用。
The methylation of histone lysine is an important covalent modification at its tails and plays a key role in epigenetic regulation.
方法采用门静脉部分缩窄（PVS）制成门静脉高压模型的30只大鼠被均分为3组：模型组（B）、左旋精氨酸组（C）、单甲基精氨酸组（D）。
Method Portal hypertension was induced by portal vein stenosis(PVS) in 30 rats subdividing into 3 groups:group B (Model), group C in which L arginine was given, and group D receiving L NAME.
组蛋白赖氨酸去甲基化酶有可能成为一个新的抗肿瘤治疗靶标。
Therefore, histone lysine demethylases may serve as a new target for anti-cancer therapy.
产生LTP的生物学基础之一是海马神经元突触上的N -甲基- D -天门冬氨酸(NMDA)受体。
And the N-methyl-D-aspartate (NMDA) receptor on the synaptosome in hippocampus is one of the biological bases of LTP.
结果表明低热量TPN有减轻肺功能损害的趋势，能够改善氮平衡和减少尿中3—甲基组氨酸的排出量；
The results showed that low calorie TPN had the tendency to lessen the functional damage of lung and could improve nitrogen balance and decrease the urine 3-MH excretion.
提示老龄大鼠血中二甲基精氨酸浓度升高可能是促进血管内皮功能不全的重要原因。
These results suggest that in the older group of rats, the elevated level of ADMA may be a contributor to vascular endothelial dysfunction.
其它：染料木素有抑制组氨酸脱羧酶，儿茶酚-O-甲基转移酶作用。
Other: The dyewood is known as the suppression histidine decarboxylase, the catecha phenol-O-methyl shift enzyme action.
目的：观察慢性复合应激对大鼠学习与记忆的影响及应激后脑海马内N-甲基-D-天冬氨酸受体亚基NR2A，NR2B表达的变化。
AIM: To study the effects of chronic multiple stress on learning and memory and changes of N-methyl-D-asparagic acid (NMDA) receptor subunits NR2A and NR2B expression in hippocampus of rats.
目的：探讨谷氨酸及其N -甲基(酰)- D -门冬氨酸受体(NMDAR1)在大鼠前额叶执行控制功能中的作用机制。
AIM: To study the effect and mechanism of glutamic acid (glu) and NMDAR1 in prefrontal cortex executive control of rats.
目的探讨吡咯喹啉醌(PQQ)对n甲基D天冬氨酸(NMDA)诱发海马神经元损伤的影响。
ObjectiveTo investigate the protective effect of pyrroloquinoline quinone (PQQ) on damage of hippocampal neurons induced by NMDA.
随着组蛋白赖氨酸去甲基化酶的发现，证实组蛋白赖氨酸甲基化是一个可以逆转的组蛋白表遗传修饰。
The discovery of the histone lysine demethylases has strongly demonstrated that histone lysine methylation is a reversible epigenetic modification.
抑制性标记由3个甲基基团组成，结合到组蛋白H4的一个赖氨酸残基上。
The repressive mark was composed of three methyl groups attached to a lysine on the H4 histone.
以蛋氨酸为原料经还原脱硫甲基化、酯化、氨解、酰胺化及分子内缩和成环4步反应合成得到了左乙拉西坦，总收率44.6%。
Levetiracetam was prepared from L-methionine via reduction-dethiomethylation, esterification, ammonolysis, amidation and intramolecular cyclocondensation reaction with 44.6% overall yield.
以蛋氨酸为原料经还原脱硫甲基化、酯化、氨解、酰胺化及分子内缩和成环4步反应合成得到了左乙拉西坦，总收率44.6%。
Levetiracetam was prepared from L-methionine via reduction-dethiomethylation, esterification, ammonolysis, amidation and intramolecular cyclocondensation reaction with 44.6% overall yield.
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