总结了组蛋白精氨酸甲基化修饰体系的最新研究进展。
Here, the most recent progresses in the methylation studies of histone arginine were summa.
甲基化修饰是脊椎动物DNA唯一的自然修饰方式，动物基因组甲基化与基因表达密切相关。
The methylation beautification is the vertebrate DNA only nature beautification way, the animal genome team methylation and the gene expression close related.
推测这类功能基因的甲基化修饰调控着相关基因的开启与关闭，为植物的生存、生长、发育及进化提供动力。
Therefore, DNA methylated modifications may be involved in the regulation of related genes, playing an important role in plant growth, development and envolution.
基因沉默的这种状态与D1基因启动子中的组蛋白甲基化和DNA甲基化修饰受抑制有关，而不涉及DNA序列的改变。
The silenced state is correlated with repressive histone and DNA methylation marks in the D1 promoter region but is not associated with DNA sequence alterations.
结果在亚苄混合物诱导的小鼠食管癌变过程中，全基因组甲基化修饰是逐渐降低的，在达到一定程度后即保持一种稳态。
It is the result that in process of pathological changes induced by nitrosamine compounds, the genome methylation level were gradually fall, and then keep the steady statements.
DNA的低甲基化可能在异常组蛋白修饰的协同下引起某些T细胞基因的异常活化，导致狼疮自身免疫的发生。
DNA hypomethylation, likely to be cooperating with aberrant histone modification, may induce the activation of some t cell genes and development of autoimmunity in SLE.
我们将在分析组蛋白修饰和DNA甲基化数据的背景下，讨论解决这些挑战的方法。
We will discuss methods to address these challenges in the context of analyzing histone modifications and DNA methylation data.
组蛋白赖氨酸甲基化是组蛋白尾段发生的一种重要共价修饰，在基因的表观遗传转录调控中起着关键的作用。
The methylation of histone lysine is an important covalent modification at its tails and plays a key role in epigenetic regulation.
表观遗传学涉及的机制主要包括DNA甲基化和组蛋白修饰及染色质重塑。
Epigenetic mechanisms, including DNA methylation, histone modification and chromatin remodeling, have been demonstrated to be involved in the development of SLE.
DNA甲基化由DNA甲基转移酶催化，在多种调节因子的参与下，与组蛋白修饰相互作用，抑制基因转录，导致基因沉默。
DNA methylation catalyzed by DNA methyltransferases interacts with histone modification to inhibit gene transcription, induce gene silencing at the participation of many regulators.
植物基因组的功能依赖于染色质标记，诸如dna的甲基化和组蛋白的转录后修饰。
The function of plant genomes depends on chromatin marks such as the methylation of DNA and the post-translational modification of histones.
表观遗传变异对于植物的生长发育起着重要作用，主要包括DNA甲基化、组蛋白修饰、染色体重塑和RNA干涉等。
Epigenetic variation plays an important role in plant growth and development, including DNA methylation, histone modification, chromosome remodeling, and RNA interference and so on.
DNA甲基化是一种主要的表观遗传修饰，对于胚胎发育、胎盘及胎儿的生长具有重要作用。
DNA methylation is a major epigenetic modification and plays a crucial role in embryonic development and placentas 'development.
DNA甲基化是脊椎动物DNA唯一的自然共价修饰方式。
DNA methylation is the unique natural covalent modification of vertebrate animals.
随着组蛋白赖氨酸去甲基化酶的发现，证实组蛋白赖氨酸甲基化是一个可以逆转的组蛋白表遗传修饰。
The discovery of the histone lysine demethylases has strongly demonstrated that histone lysine methylation is a reversible epigenetic modification.
主要探讨组蛋白共价修饰中乙酰化和甲基化在消化道肿瘤形成过程中的作用。
This review focuses on how aberrant covalent histone modifications such as acetylation and methylation may contribute to the development of alimentary canal neoplasms.
DNA甲基化是真核细胞基因组最常见的一种表观遗传学修饰。
DNA methylation is one of the most common epigenetic events in eukaryotic cell.
DNA甲基化是基因表达的重要调控方式，是真核细胞中最常见的转录水平的修饰方式之一。
DNA methylation is an important regulation of gene express in eukaryotic cells, and is one of the most common modifications of the transcription level.
表遗传学机制在肺癌的形成中占据重要地位，包括DNA的甲基化和组蛋白修饰，肺癌中与癌形成有关基因的失活多与异常甲基化有关，并且组蛋白修饰和甲基化紧密联系着。
Aberrant methylation may be the most common mechanism of inactivating cancer-related genes in lung cancer, and histone modification may be closely associated with DNA methylation.
活化的差异组蛋白修饰标记物对抑制基因的改变伴随着这些DNA甲基化改变。
Differential histone modification marks of active versus repressed genes accompany these DNA methylation changes.
DNA甲基化是真核生物DNA的正常内源性修饰方式，它由DNA甲基化转移酶催化发生。
DNA methylation is a kind of normal endogenous modified mode, which is fulfilled by DNA methylation transferase.
在已知的表观遗传修饰中，DNA甲基化似乎在白血病形成中起到一个重要的作用。
DNA methylation, amongst the known epigenetic modi?cations, appears to play a crucial role in leukaemogenesis.
赖氨酸甲基化是组蛋白共价修饰之一，在多种生物学过程有重要作用。
One such modification, lysine methylation, has important functions in many biological processes.
赖氨酸甲基化是组蛋白共价修饰之一，在多种生物学过程有重要作用。
One such modification, lysine methylation, has important functions in many biological processes.
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