方法：向实验组大鼠鞘内注射一种缝隙连接的阻断剂甘珀酸；
Methods: Experimental rats were intrathecally injected with carbenoxolone(CBX), a special gap junction blocker, and the control rats with the saline.
目的：探讨缝隙连接阻断剂甘珀酸对大鼠光化学局灶性脑梗死神经元损害的影响。
AIM: To explore the effects of carbenoxolone (CBX), a gap junction blocker, on the neuron injury induced by focal cerebral infarct.
结论：在整体动物甘珀酸预处理可以导致癫痫发作增强，这可能与星形胶质细胞增生及其连接蛋白43表达升高有关。
CONCLUSION: the seizure can be enhanced by CBX pretreatment and it may relate with astrocytic hyperplasia and the increasing expression of Cx43 in astrocytes.
结论：在整体动物甘珀酸预处理可以导致癫痫发作增强，这可能与星形胶质细胞增生及其连接蛋白43表达升高有关。
CONCLUSION: the seizure can be enhanced by CBX pretreatment and it may relate with astrocytic hyperplasia and the increasing expression of Cx43 in astrocytes.
应用推荐