方法：采集健康的牙龈组织和牙周膜，体外培养牙龈成纤维细胞和牙周膜成纤维细胞。
Methods: Healthy human gingiva and periodontal ligament were acquired from patients, then gingival fibroblasts and periodontal cells were cultured in vitro.
目的：观察模拟咬合压力对人牙周膜成纤维细胞环氧化酶2 (COX 2)基因表达的影响。
Objective: To investigate the influence of simulated occlusion pressure on the cyclooxygenase-2 (COX-2) gene expression in human periodontal ligament fibroblasts (HPLFs).
结论：SP - PLGA纳米微球通过持续释放活性SP，可在较长时间内促进牙周膜成纤维细胞的增殖。
Conclusion: It suggested SP-PLGA can promote the proliferation of human periodontal ligament fibroblasts through a long period of controlled release of SP.
目的：探讨牙周膜成纤维细胞与可吸收引导组织再生膜生物相容性，为牙周组织工程中支架材料选择提供依据。
Objective: To evaluate the biocompatibility on guided tissue regeneration membranes combined with cultured human periodontal ligament fibroblasts (PDLFs) in periodontal tissue engineering.
结果：加载模拟咬合压力的人牙周膜成纤维细胞COX 2表达水平明显高于对照组，而且在一定范围内表达水平与加压力值成剂量依赖关系；
Res ults: COX-2 expression level in HPLFs loaded with intermittent simulated occlusion pressure was significantly higher than that in the controls in a magnitude-dependent manner.
结果：加载模拟咬合压力的人牙周膜成纤维细胞COX 2表达水平明显高于对照组，而且在一定范围内表达水平与加压力值成剂量依赖关系；
Res ults: COX-2 expression level in HPLFs loaded with intermittent simulated occlusion pressure was significantly higher than that in the controls in a magnitude-dependent manner.
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