本发明涉及重组多肽，特别是结合纤连蛋白的Ed-B-同种型并可阻断其功能的抗体或抗体片段。
The invention relates to recombinant polypeptides, in particular antibodies or antibody fragments, which are able to bind the ED-B isoform of fibronectin and block the function thereof.
本发明也揭示包含所述抗rage抗体及其RAGE结合抗体片段的医药组合物及其用于治疗RAGE相关疾病的用途。
Also disclosed are pharmaceutical compositions comprising such anti-RAGE antibodies and RAGE-binding antibody fragments thereof, and their use for treatment of RAGE related diseases.
竞争抑制实验表明所获人源抗体片段与亲本鼠源单抗结合同一抗原表位。
Binding competition studies demonstrated that they bound the same epitope of the Ag as the parental Ab.
本发明揭示与晚期糖化终产物受体(RAGE)特异性结合的抗体及其RAGE结合片段。
Antibodies that bind specifically to receptor for advanced glycation end products (RAGE) and RAGE-binding fragments thereof are disclosed.
本发明也提供结合至该TF的人源化抗体及其片段。
Also provided are humanized antibodies and fragments thereof that bind to the TF.
特别的，细胞结合剂是识别并结合CD38蛋白的单 克隆抗体、其表位结合片段。
In particular, the cell binding agent is a monoclonal antibody, and epitope-binding fragments thereof, that recognizes and binds the CD38 protein.
特别的，细胞结合剂是识别并结合CD38蛋白的单 克隆抗体、其表位结合片段。
In particular, the cell binding agent is a monoclonal antibody, and epitope-binding fragments thereof, that recognizes and binds the CD38 protein.
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