下一步是精确地研究一个EGF R激酶结构域是如何开启另外一个激酶的。
The next step was to pinpoint how one EGFR kinase domain would switch on another.
是一个新的肿瘤相关基因，其结构上与受体蛋白相似，具有一个蛋白激酶结构域。
Novel Oncogene with Kinase-domain (NOK) is a novel tumor-related gene, coding receptor like protein with a kinase domain.
人们很早就知道，EGFR配体使受体二聚化，这种二聚化导致激酶结构域的激活；
It had long been known that the EGFR ligand dimerizes the receptor and that this dimerization converts into an activation of the kinase domain;
霍华德·休斯医学研究所的研究人员现已经得知，这种配对导致了激酶结构域形状上的物理变化。
HHMI researchers have now learned that this pairing causes a physical change in the shape of the kinase domain.
酪氨酸576和酪氨酸577处于激酶结构域的激活环，这些残基的突变减弱FAK的催化活性（6）。
Tyr576 and Tyr577 lie in the activation loop of the kinase domain, and mutation of these residues reduces FAK catalytic activity (6).
他们发现，在较大比例患有肺癌的病人中，可以激活EGFR的特定突变能导致激酶结构域活性增加20倍。
They found that a particular mutation that activates EGFR in a large percentage of patients with lung cancer caused a 20-fold increase in the kinase domain's activity.
经尿素变性、梯度透析复性及去除GST“标签”后，获得重折叠的人EGFR胞内酪氨酸激酶结构域蛋白。
After denaturing in urea, gradient dialysis and cleavage of GST-tag, refolded human EGFR-TKD was obtained.
提供了用于在具有次级EGFR突变，特别地酪氨酸激酶结构域突变的抗标准疗法的个体中治疗癌症和减少肿瘤生长的方法。
Methods for treatment of cancer and reduction of tumor growth in individuals with secondary EGFR mutations, particularly tyrosine kinase domain mutations, resistant to standard therapy are provided.
第一章共分为四节：第一节介绍了PKB的结构特征，对其三大结构域：PH结构域、激酶结构域、调节结构域，进行了详细描述。
The first chapter is divided into four sections. The first section gave a detailed description of the structure of PKB's three major domains: PH domain, kinase domain and regulate domain.
他们发现，由一个分子对另外一个EGFR激酶结构域的不对称激活类似于涉及调控细胞生长的细胞周期蛋白激活细胞周期蛋白依赖型激酶的方式。
They found that the asymmetric activation of one EGFR kinase domain by another is analogous to the activation of cyclin-dependent kinase (CDK) by cyclin, which are involved in regulating cell growth.
结果表明：阿维链霉菌中存在61个组氨酸蛋白激酶，其中30个组氨酸蛋白激酶包含了全部的保守传递器结构域。
The result showed that 61 histidine kinases were found in the genome and 30 histidine kinases contained total conserved transmitter domain.
根据其胞外受体结构域的组成不同，植物受体蛋白激酶可划分为不同的类型。
Based on structural similarities in their extracellular domains the RPKs fall into five categories.
极光激酶A催化结构域苏氨酸（288位）的磷酸化能够增强激酶的活性。
Phosphorylation of Aurora A at Thr288 in its catalytic domain increases kinase activity.
序列分析表明，其结构与所有已知的抗真菌蛋白不同，而与富含半胱氨酸的植物类受体激酶的胞外结构域相似。
The protein showed no similarity to other pathogenesis-related proteins but did show homology to the extracellular domain of plant cysteine-rich receptor-like kinases.
序列分析表明，其结构与所有已知的抗真菌蛋白不同，而与富含半胱氨酸的植物类受体激酶的胞外结构域相似。
The protein showed no similarity to other pathogenesis-related proteins but did show homology to the extracellular domain of plant cysteine-rich receptor-like kinases.
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