在心肌细胞中,T3结合到细胞核中的甲状腺激素受体,其依次结合靶基因调节区中的甲状腺激素反应元件以调节转录。
In the cardiomyocyte, T3 binds to thyroid hormone receptors in the nucleus, which in turn bind to thyroid hormone response elements in the regulatory regions of target genes to regulate transcription.
以含雌激素反应元件的荧光素酶(ERE -LUC)为报告基因,通过检测荧光素酶活性来确定MDM2是否对ER有转录调节因子的作用。
The effect of MDM2 on the transcriptional activity of er was detected by the reporter gene containing estrogen responsive elements luciferase (ERE-LUC).
这些核激素受体由其配体(激活物)激活后,通过偶联特异的反应元件来调控多种靶基因的表达。
After activation by ligand as is the case with nuclear receptors, PPARs binds to a specific element in the promoter region of target genes.
这些核激素受体由其配体(激活物)激活后,通过偶联特异的反应元件来调控多种靶基因的表达。
After activation by ligand as is the case with nuclear receptors, PPARs binds to a specific element in the promoter region of target genes.
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