原发性系统性淀粉样变的治疗。
医生将淀粉样变性分为三种主要类型。
家族史、有些病例显示，淀粉样变能遗传。
它们改变了这个酶切割淀粉样蛋白前体的方式。
淀粉样变的严重性依赖于淀粉样蛋白沉积在哪个器官。
The severity of amyloidosis depends on which organs the amyloid deposits affect.
然而并不是所有人都认为应该把焦点放在淀粉样蛋白上。
Not everybody believes that focusing on amyloid is the right way to go, however.
这个样本会送往实验室在显微镜下检查是否有淀粉样蛋白沉积。
The sample is then examined under a microscope in a laboratory to check for signs of amyloid.
当淀粉样变侵袭心脏电传导系统，就会影响到心脏跳动的节律。
And when amyloidosis affects the electrical system of your heart, this may disturb your heart's rhythm.
严重的淀粉样变并发症如肾衰竭和充血性心力衰竭会危及生命。
Potentially life-threatening situations include kidney failure and congestive heart failure.
原发性淀粉样变的病因并不明了，但医生可以确定病变起于骨髓。
The exact cause of primary amyloidosis is unknown, but doctors do know that the disease begins in your bone marrow.
淀粉样蛋白通常由骨髓细胞合成，可以在各个组织和器官中沉积。
Amyloid is an abnormal protein usually produced by cells in your bone marrow that can be deposited in any tissue or organ.
研究人员研究了多种治疗手段，确定了它们在治疗淀粉样变中的地位。
Researchers are studying several therapies to determine their place in the treatment of amyloidosis.
如其名，这种淀粉样变是遗传的，病变通常侵袭肝脏，神经，心脏和肾脏。
As the name implies, this form of amyloidosis is inherited. This type often affects the liver, nerves, heart and kidneys.
这种疾病的众多隐秘信号之一是在脑中的B -淀粉样蛋白斑块中的沉积。
One of the telltale signs of this disease is the deposit of beta-amyloid plaques in the brain.
淀粉样蛋白的斑块被认为“堵塞”了大脑，并且造成了神经死亡与功能丧失。
Plaques of beta-amyloids are thought to "silt up" the brain and cause nerve death and loss of function.
原发性淀粉样变通常不伴有其他疾病——骨髓肉瘤(一种骨髓恶性肿瘤)除外。
Primary amyloidosis isn't associated with other diseases - except for multiple myeloma, a form of bone marrow cancer.
淀粉样β蛋白本身可能损伤神经细胞或者有它聚集形成的老年斑才是罪魁祸首。
Amyloid beta itself might be injuring nerve cells or the plaques, made of accumulations of amyloid beta, could be the culprits.
LEHRER：你的书介绍了一种新技术，医生可以成像脑中的淀粉样蛋白斑块。
LEHRER: Your book talks about a new technique that allows doctors to image amyloid plaques in the brain.
而阻止增食欲素起作用的药剂会导致淀粉样蛋白含量大大降低，并增加睡眠时间。
A drug that blocked the action of orexin led to a significant reduction in levels and increased the amount of sleep.
贝塔(以贝塔-淀粉样斑块的形式)和陶(以陶蛋白缠结的形式)是痴呆症的物质表征。
Beta (in the form of beta-amyloid plaques) and tau (in the form of tau tangles) are the physical manifestations of Alzheimer's.
淀粉样变另一严重的并发症是神经系统病变，包括腕管综合征——以手指麻木刺痛为特点。
Another potential complication of amyloidosis is disruption of your nervous system function. This may include carpal tunnel syndrome - characterized by pain, numbness or tingling of the fingers.
FDA说有理由不接受其他形式的证明，如扫描结果或显示脑部淀粉样蛋白变化的脑脊液。
There is reason not to accept other forms of proof, like scans or cerebrospinal fluid that show changes in amyloid in the brain, the F.D.A. says.
博士们正在用新的技术来检测淀粉样蛋白，它是一个可以引起斑块的蛋白导致阿尔茨海默病。
Doctors are also beginning to use new technology to detect amyloid, a plaque-causing protein that can lead to Alzheimer's disease.
Selkoe还说：“在我看来，轻度老年痴呆症患者是降低淀粉样蛋白试验的最佳对象。”
“In my view, the sweet spot for amyloid-lowering trials is mild Alzheimer’s disease, ” Dr. Selkoe said.
因此过去20年，注意力一直集中在研发那些能将淀粉样蛋白斑从被感染的大脑中除掉的药物。
For the past two decades, therefore, most attention has been given to developing drugs that will remove amyloid plaques from an affected brain.
传统的治疗老年痴呆症的药物研发思路仅仅集中在淀粉样β蛋白的累积上，Nixon博士说。
Traditional drug development in Alzheimer's disease is taking too narrow an approach by focusing intensively on the buildup of amyloid beta-protein in the brain, Dr. Nixon says.
遗传性(家族性)淀粉样变。如其名，这种淀粉样变是遗传的，病变通常侵袭肝脏，神经，心脏和肾脏。
Hereditary (familial) amyloidosis. As the name implies, this form of amyloidosis is inherited. This type often affects the liver, nerves, heart and kidneys.
如果你患有继发性淀粉样变，首先要治疗的是原发疾病——如对类风湿性关节炎来说，首先要抗炎治疗。
If you have secondary amyloidosis, the goal of therapy is to treat the underlying condition - for example, taking an anti-inflammatory medication for inflammatory arthritis.
使用复杂的扫描技术，她的团队已经在脑中的淀粉样蛋白斑块中特异性的定位了这种疱疹病毒的DNA。
Using sophisticated scanning techniques, her team has located DNA of this herpes virus specifically within the amyloid plaques in the brain.
直到最近，科学家们才将注意力集中到了淀粉样蛋白肽上，提出通过减少其积聚来减轻大脑的负担的策略。
Until recently, scientists have focused their attention on the amyloid plaques and finding ways to shrink them to relieve the burden on the brain.
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