自然界中有一类名为转录因子的蛋白可调节(升高或者降低)基因的活性，该技术正是基于该机理。
The technique relies on a natural process by which the activity of genes is raised or lowered by proteins called transcription factors.
作为端粒酶活性的关键决定因子，端粒酶逆转录酶的调控研究已取得了重大进展，但具体机制仍不清楚。
As a critical factor of telomerase activity, much progression has been achieved in the study of regulation of human telomerase reverse transcriptase, but the detail mechanism is still not clear.
具体地，本发明显示E2-EPF5活性的抑制降低VEGF以及其他在低氧应答中由转录因子HIF-1调节的蛋白质的产生。
In particular, inhibition of E2-EPF5 activity is shown to reduce the production VEGF, as well as other proteins regulated the transcription factor HIF-1, in response to hypoxia.
以含雌激素反应元件的荧光素酶(ERE -LUC)为报告基因，通过检测荧光素酶活性来确定MDM2是否对ER有转录调节因子的作用。
The effect of MDM2 on the transcriptional activity of er was detected by the reporter gene containing estrogen responsive elements luciferase (ERE-LUC).
紫外辐射后第315位丝氨酸发生在体磷酸化已被观察到，而且Ser315Ala突变的p53能够减少其作为转录因子的活性（17）。
In vivo phosphorylation at Ser315 has been observed following UV-irradiation, and a Ser315Ala mutant p53 has reduced activity as a transcription factor (17).
目的探讨表面活性蛋白B（SP-B）与甲状腺转录因子（TTF-1）在新生儿肺透明膜病中的表达及其意义。
Objectives To study the expression of surfactant protein B(SP-B)and thyroid transcription factor 1(TTF-1)and evaluate the role in neonatal hyaline membrane disease(NHMD).
目的探讨甲状腺转录因子1 (TTF 1)和表面活性蛋白a、B (SP A,SP B)在肺硬化性血管瘤(PSH)中表达的生物学意义。
Objective to investigate the biologic significance of thyroid transcription factor-1 (TTF-1) and surfactant protein a (SP-A) and SP-B expression in pulmonary sclerosing hemangioma (PSH).
目的探讨内毒素（LPS）诱导的急性肺损伤（ALI）大鼠肺组织甲状腺转录因子-1（TTF-1）、肺表面活性物质相关蛋白-A（SP-A）表达的变化。
Objective To investigate the change of the expression of TTF-1 and SP-A in lung tissue of ALI rats induced by LPS.
前言： 近年来，一些不依赖于转录因子活性的新型双杂交系统相继建立，如分离的泛素系统、 蛋白质片段互补分析、阻遏物重构分析和SOS恢复系统等。
Some new type of two-hybrid systems, such as split-ubiquitin system, protein-fragment complementation assay, repressor reconstitution assay and SOS recruitment system, have been developed recently.
1985年Aaron先生发现了一类具有与转录因子类似功能的新的蛋白；该蛋白能够识别特定的DNA区域并且结合上去，从而导致基因活性上升或者下降。
In 1985 Sir Aaron discovered a new class of proteins that mimic this function and can recognise specific stretches of DNA and bind to them, boosting the activity of genes or damping them down.
此外，活性增强的核转录因子- kB未被逆转。
Additionally, increased activity of nuclear factor-kB was not reversed.
此外，活性增强的核转录因子- kB未被逆转。
Additionally, increased activity of nuclear factor-kB was not reversed.
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