更具 体来说,本发明涉及在炎症和自身免疫疾病中识别人抑制性CD200R并调节其活性的抗体。
More specifically, the invention relates to antibodies that recognize the human inhibitoryCD200R and modulates its activity in inflammatory and autoimmune disorders.
目的探讨在不同的免疫学检测方法中,与单链抗体相连的亲和标记肽对单链抗体与抗原结合活性的影响。
Objective to investigate the affects of affinity tag on binding activity of single chain variable fragment (ScFv) to antigen using different immunological assays.
在免疫组化实验步骤中,使用一个阻断试剂去评价抗体活性的特异性。
Use as a blocking reagent to evaluate the specificity of antibody reactivity in immunohistochemistry protocols.
抗人淋巴毒素的单克隆抗体能中和它的细胞毒活性。
Its cytotoxic activity can be neutralized by monoclone antibody against hLT.
结合物免疫小鼠所诱生的血清GAMP抗体较之多糖组具有更强的体外杀菌活性。
The complement-dependent bactericidal experiment showed that serum GAMP antibodies induced by the conjugate had stronger bactericidal activity.
人源抗体制备的瓶颈是获得高表达、高产量、高活性抗体。
The bottleneck of preparation of human antibody is that obtained effective expression and production with higher activity.
因此,制备具有加氯过氧化物酶活性的催化抗体用于机制研究和治疗应用是相当有意义的。
Therefore, it will be of considerable interest to prepare a catalytic antibody with chloroperoxidase activity for mechanistic studies and therapeutic application.
纯化的卵黄抗体分别置于6个EP管中,1~4号管的卵黄抗体仍有活性,第5管和第6管出现白色沉淀,可能是较高温度下蛋白变性引起的。
Purified IgY was added to six EP tubes, the number 1-4 still had partial activity, but number 5 and 6 showed some white precipitate, which was caused by protein denaturation at higher temperature.
当今市场上的几种治疗癌症的抗体能够杀死癌细胞的主要作用机理之一就是具有adcc活性。
Several anti-cancer therapeutic antibodies that are on the market today have ADCC activity as one of their mechanisms for the killing of tumor cells.
宫宁口服液尚可以提高小鼠的NK细胞活性,增强免疫抑制状态下的小鼠的迟发型皮肤超敏反应,促进溶血素抗体的生成。
Gong Ning Oral Liquid could also enhance NK cell activity, increase the delayed type hypersensitivity reaction under immunosuppressive state and promote production of inhibition of serum hemolysin.
这些单克隆抗体显示出适于用作药物的生物活性。
These monoclonal antibodies show biological activities suitable for using as drugs.
本发明公开了一种具有内化活性的抗hb -EGF抗体。
An anti-HB-EGF antibody having an internalizing activity is disclosed.
目的研究人体产生的抗-D抗体的体外生物学活性。
Objective To evaluate the biological activity of anti-Rh (d) antibodies in vitro.
细胞水平的体外活性评价试验显示抗体有较好的抑制肿瘤生长的生物学活性。
In vitro activity of antibody was evaluated and the result manifested that it has a high biological activity.
巨噬细胞活性增强是否也与抗体量的增长有关,尚待进一步研究。
The further research will prove whether the reinforced activity of the macrophage is related with the increase of antibody's number.
CIA形成的早期关节组织内可能产生大量的VEGF,并以较强的生物活性形式存在,能被抗vegf中和抗体抑制。
During early stage of CIA development, expression of VEGF in the joint increases and VEGF is expressed biologically active and can be inhibited by anti VEGF neutralizing antibody.
目的:鉴定自制的抗CD3-抗胶质瘤双特异性抗体(双抗)的双向结合能力,测定其免疫活性及其对T淋巴细胞的作用。
Objective: To study bidirectional binding ability and immunoactivity of anti-CD3/anti-glioma bispecific antibodies(BsAb) , and to study its effect on T lymphocytes cells.
用免疫放射双抗体夹心法测定,标记抗体能保持良好的免疫活性。
The labelled antibody showed good immunoreactivity, when it was measured by IRMA-bi-antibody sandwich method.
同时,利用此重组蛋白为抗原,制备了小鼠组织因子的小鼠源功能阻断性单克隆抗体,在血浆凝集实验中证明其对小鼠组织因子的活性有明显抑制作用。
Using this recombinant mTF as immunogen, a murine monoclonal function-blocking antibody to mTF was also generated, which can inhibit mTF-initiated plasma clotting in vitro.
淋巴细胞亚群的改变和NK细胞活性降低,导致B细胞功能亢进,产生多种自身抗体,在SLE的发病机理中起重要作用。
The changes of peripheral T lymphocyte subsets and decrease of NK cells, which lead to proliferation of B cells, may play an important role in the development of SLE.
用表面呈现技术构建文库并从中筛选新的生物活性物质,如抗体、受体或疫苗,已成为研究生物新药的捷径之一。
Screening novel products with bioactivities, such as antibodies, receptors and vaccines has become a convenient way to develop novel biopharmaceuticals.
目的制备高活性的可溶性抗人血管生长素噬菌体基因工程抗体。
Objective To prepare the high effective and soluble genetic engineering antibody of anti-human angiogenin.
由于青蒿素抗体活性比马兜铃酸抗体活性强,因此检测出的青蒿素极限浓度较低。
The sensitivity of detecting Artemisinin is higher due to its antibody is more active than that of Aristolochic acid antibody.
第三,干扰素抗体的吸收峰与其活性峰相一致;
Third, the peak of absorbent titer of human leucocyte interferon antibody coincided with that of interferon activity;
NKG2D配体表达上调可有效提高NK细胞的细胞毒活性,此效应可被抗NKG2D抗体所阻断。
The up-regulation of NKG2D ligands increased the cytotoxicity of NK cells efficiently, and this effect could be blocked by anti-NKG2D antibody.
并在此过程中采用类“双抗原夹心酶联免疫法”对乙肝抗体的活性及优化效果进行了检测。
The activity of HBsAb on magnetic beads was detected by the method similar to Enzyme-Linked Immunosorbent Assay (ELISA).
结论:标记抗体在体外对单核、巨噬细胞显示了相对特异的杀伤活性。
Conclusion The conjugation can show a highly specific cytotoxicity upon mononuclear-macrophage in vitro.
结论:标记抗体在体外对单核、巨噬细胞显示了相对特异的杀伤活性。
Conclusion The conjugation can show a highly specific cytotoxicity upon mononuclear-macrophage in vitro.
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