热休克因子1 (HSF1)是一种转录因子，在正常时不活化，应激时活化而具有反式激活能力。
As a transcription factor, heat shock transcription factor 1 (HSF1) is activated during stress and subsequently trans-activate its downstream factors.
在正常生长条件下，热激因子处于钝化的单体状态，而当热激时，热激因子形成三聚体并与DNA结合，同时通过转录激活域的活化而激活热激基因的表达。
HSF is present in a latent state under normal conditions; it is activated upon heat stress by induction of trimerization, high affinity binding to DNA and transcriptional activity.
大多数雄激素非依赖性前列腺癌均高表达AR和核受体辅活化子、如转录中间因子2（TIF-2），ARA24、PIAS、类固醇受体辅活化子-1（SRC-1）等有力地支持了这个假说。
The "superactive AR"hypothesis was supported by the fact that the majority of AIPC expresses high level of AR and nuclear receptor(NR) coactivators, such as TIF-2, ARA24, PIAS, SRC-1.
核受体是配体活化的转录因子，能调控大量的靶基因。
Nuclear receptors (NRs) are ligand-activated transcription factors that regulate the activation of a variety of important target genes.
本专利提 出了一种检测转录因子表达和活化水平的新方法“核酸外切酶III消化微孔板包被特殊标记双链核酸分子检测转录因子蛋白”。
The present invention proposes exonuclease III digesting double stranded nucleic acid molecule coated in microporous plate and containing special marker to detect transcription factor protein.
目的探讨大鼠急性肺损伤（ALI）过程中，信号转导和转录活化因子-3（STAT3）的活化，及其与细胞因子白介素-6（IL-6）的相关性。
Objective To investigate the activation law of signal transducers and activators of transduction-3(STAT3) and whether cytokine IL-6 can activate STAT3 in acute lung injury (ALI) of rats.
目前对这一现象有四种解释：ROS活化核转录因子KB并诱导核转录因子-KB表达，导致细胞凋亡；
At present, the explanations for this phenomenon are: 1) ROS activated nuclear factor-KB and induction of the expression of nuclear factor-KB; 2) mitochondria-mediated cell apoptosis;
信号转导及转录活化因子3（STAT3）是STAT家族成员之一，也是肿瘤组织中的常见通路。
STAT3, as a member of signal transducers and activators of transcription (STATs) family, which has been recognized as one of the common pathways in cancer cells.
信号转导及转录活化因子3（STAT3）是STAT家族成员之一，也是肿瘤组织中的常见通路。
STAT3, as a member of signal transducers and activators of transcription (STATs) family, which has been recognized as one of the common pathways in cancer cells.
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