现综述波生坦的药理学、药动学和临床应用方面的进展。
The pharmacology, pharmacokinetics, and clinical applications of bosentan are reviewed in this paper.
方法：单中心，随机，前瞻性，双盲比较波生坦和安慰剂。
Methods. Single-centre, randomized, prospective, double-blinded comparison of bosentan and placebo.
内皮素受体拮抗剂波生坦是治疗肺动脉高压的有效药物之一。
The endothelin receptor antagonist bosentan is one of the effective drugs for pulmonary arterial hypertension.
本文简要介绍了左乙拉西坦和波生坦的药理作用及其合成意义。
We briefly discussed pharmacology and significance of both levetiracetam and bosentan in the paper.
目的：探讨波生坦治疗肺动脉高压的药理机制，并评价其临床疗效和用药安全性。
OBJECTIVE: To study pharmacological mechanism of bosentan for treatment of pulmonary artery hypertension (PAH) and evaluate its clinical efficacy and the safety.
结果表明，应用波生坦后，尽管收缩期和舒张期血压没有变化，收缩末期和舒张期心室体积比例明显升高。
Peak systolic and diastolic strain rates also increased significantly after bosentan treatment, the results indicate, although systolic and diastolic blood pressures were not affected.
他是一个叫做那波里坦的意粉厨师的儿子，其一生参与制作过的电影有500部左右。
The son of a Neapolitan pasta-maker, he was linked to about 500 films.
他是一个叫做那波里坦的意粉厨师的儿子，其一生参与制作过的电影有500部左右。
The son of a Neapolitan pasta-maker, he was linked to about 500 films.
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