目的应用PCR方法获得水蛭素基因。
PurposeThe aim is to obtain recombinant hirudin gene using PCR method.
目的：探讨复方水蛭素抗肿瘤的作用机理。
Objective: To investigate the anti-tumor mechanism of hirudin.
水蛭素抗凝作用明显强于潘生丁（P<0.01）。
The anticoagulation effect of hirudin was better than dipyridamole (P<0.01).
水蛭素组患者的血脂也有改善，但差异无统计学意义；
The blood lipid was also ameliorated in hirudintreated group, but there was no significant difference.
目的：观察水蛭素对大鼠随意皮瓣淤血模型成活保护作用。
OBJECTIVE: To investigate the protective effect of hirudin on random skin flap congestion.
目的：运用DNA家族改组方法提高水蛭素的抗凝血酶活性。
AIM: To directed promote the antithrombotic activity of hirudin in vitro with DNA family shuffling method.
水蛭素具有较好的药理作用，其药源丰富，在临床上应用广泛。
Hirudin has good pharmacological action, which is widely used in clinical practice.
但是天然水蛭素产量低，价格昂贵，限制了它在临床上的运用。
However, low production of natural hirudin, which was very expensive, limiting its use of in clinical practice.
作为直接凝血酶抑制剂，重组水蛭素在临床上的应用已越来越重要。
As a direct thrombin inhibitor, recombinant hirudin (r-hirudin) has played an important role in clinical use.
结论凝血酶对丘脑组织具有毒性损伤作用，但这一损伤可被水蛭素逆转。
Conclusion Damage to the thalamic tissue might be caused by thrombin and reversed by hirudin.
结果所制备的重组水蛭素肠溶包衣微丸药物含量质量分数为3.513%。
Results The drug content of prepared recombinant hirudin coated-pellets was 3.513% (w).
目的研究水蛭素样肽（HLP）对兔粥样硬化颈动脉成形术后再狭窄的干预作用。
Objective To examine the effect of hirulog-like peptide (HLP) on angioplasty-induced restenosis in the carotid arteries of atherosclerotic rabbits.
目的探讨凝血酶对脑组织损害的机制，及凝血酶抑制剂水蛭素和尼莫地平对其的影响。
Objective To investigate the mechanism of brain injury caused by thrombin and the intervention effect of hirudin and nimodipine.
结论重组水蛭素经蟾蜍肺泡膜的转运是一个非能量依赖、非载体依赖的被动扩散过程。
CONCLUSION The transport of recombinant hirudin across xenopus pulmonary membrane was a passive diffusion process which was energy-independent and carrier-independent.
结果：在同侧基底节，明胶海绵吸附上凝血酶引起明显脑水肿，水蛭素能减轻脑水肿。
Results:Thrombin soaked gelatin sponges caused significant brain edema in the right basal ganglia. Hirudin prevented thrombin induced edema. Conclusion:Thrombin soaked gelation sponges can cause o…
结论实验表明，水蛭素活性因子对S180肿瘤和CAM新生血管具有较强的抑制作用。
ConclusionThe experiments show that hirudin active factors have strong inhibition effect on S180 Tumor and CAM angiogenesis.
目的探讨水蛭素活性因子对S180肿瘤及血管新生的影响，为临床用药提供理论依据。
ObjectiveTo explore the effect of hirudin active factor on S180 tumor and angiogenesis so as to provide the theoretical basis for clinical medication.
重组水蛭素鼻腔喷雾剂长期给药对鼻黏膜结构有一定影响，但此作用可在停止给药后恢复。
HVS was able to damaged the nasal epithelium, but this effect recovered soon after sloping administration.
水蛭素在噬菌体表面的功成展示为进一步开展其实验定向进化以及结构与功能关系的研究打下基础。
The successful display of hirudin on the surface of M13 phage laid a sound foundation for the further study on directed evolution of antithrombotic proteins with altered properties.
两组发生副作用的病例数均较少，水蛭素组胃肠道不良反应的发生率也显著低于潘生丁组（P<0.05）。
Few side effects were found in both groups, and the rate of adverse reaction in gastrointestinal tract was lower in hirudintreated group as compared with that in dipyridamoletreated group (P<0.05).
从水蛭素药理作用、剂量及安全性、稳定性方面，对水蛭素的可利用性进行了分析，旨在为相关研究奠定基础。
The pharmacological action, dose, security and stability of hirudin are summarized, and its availability is analyzed to provide some references for the relevant research.
目的探讨凝血酶对体外培养的原代大鼠脑微血管内皮细胞(bmvec)的损伤作用及凝血酶抑制剂水蛭素的保护作用。
AIM to investigate the apoptotic effect of thrombin on brain microvascular endothelial cell (BMVEC) of cultured rat, and the protective effect of hirudin, an inhibitor of thrombin.
水蛭素是特异的直接作用于凝血酶的抗凝剂。本文概述了其分子生物学特性、药理学特征、作用机理以及临床应用状况。
Hirudin is an anticoagulant directly acting on thrombin. Its molecular biological and pharmacological properties, mechanism of action, current clinical researches and USES were reviewed.
结论凝血酶可以引起脑出血后脑组织水肿，水蛭素可以抑制凝血酶所引起的脑水肿且水蛭素本身不对脑组织产生负面影响。
Conclusion Thrombin can lead to brain edema after cerebral hemorrhage which can be restrained by hirudin. And then, hirudin doesn't produce any negative effect on brain tissue.
结论凝血酶可以引起脑出血后脑组织水肿，水蛭素可以抑制凝血酶所引起的脑水肿，且水蛭素本身不对脑组织产生任何负面影响。
Conclusion Thrombin lead to brain edema after cerebral hemorrhage that could be restrained by hirudin, and hirudin didn't produce any negative effect on brain tissue.
本发明提供了一种治疗肝素相关性血小板减少症的药物组合，其主要成分包括可接受药物量的重组水蛭素及其医药上可接受的盐。
The invention provides a medicine composition for curing heparin-induced thrombocytopenia. The main components include Lepirudin and salt which can be accepted by the medicine.
本文介绍了他们的作用机理及其临床研究，叙述了他们与肝素相比的优越之外，认为水蛭素与水蛭肽是两类非常有前途的抗栓新药。
This paper introduces their mechanism function and clinical research illustrates their advantages compated with heparin believing that both hirudin and hirulog are new promising antithrombotic agents.
本文介绍了他们的作用机理及其临床研究，叙述了他们与肝素相比的优越之外，认为水蛭素与水蛭肽是两类非常有前途的抗栓新药。
This paper introduces their mechanism function and clinical research illustrates their advantages compated with heparin believing that both hirudin and hirulog are new promising antithrombotic agents.
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