研究了一种直接环合的方法，用2-氯-2氯甲基- 4-氰基丁醛与三氯氧磷反应来制备2-氯-5-氯甲基吡啶。
A synthetic method of direct cyclization was researched that 2-chloro-2-chloromethyl-4-cyanobutyraldehyde was reacted with phosphorus oxychloride to get 2-chloro-5-chloromethylpyridine.
本文用2-氯-5-氯甲基吡啶经氨基化，和N-氰基乙亚胺酸乙酯反应，最后甲基化得到吡虫清。
In this thesis, 2-chloro-5-chloromethyl pyridine is ammoniated, which followed by the reaction with N-cyano ethyl ethylimidoate, finally is methylated to gain the objective product.
以4甲基吡啶为原料，在固定床反应器中通过含氧化钒的催化剂发生气固相接触氨氧化反应制备雷米封中间体4氰基吡啶，4甲基吡啶的转化率为99%，4氰基吡啶的选择性为88%，收率为87。
4-cyanopyridine, intermediate of rimifon, was synthesized from 4-picoline using vanadium oxide as a catalyst in a fixed-bed reactor, reached 99% conversion of 4-picoline, 88% selectivity and 87.
以4甲基吡啶为原料，在固定床反应器中通过含氧化钒的催化剂发生气固相接触氨氧化反应制备雷米封中间体4氰基吡啶，4甲基吡啶的转化率为99%，4氰基吡啶的选择性为88%，收率为87。
4-cyanopyridine, intermediate of rimifon, was synthesized from 4-picoline using vanadium oxide as a catalyst in a fixed-bed reactor, reached 99% conversion of 4-picoline, 88% selectivity and 87.
应用推荐