目的研究氯通道阻滞剂对肾小球系膜细胞增殖的作用。
Aim To investigate effects of chloride channel blockers on proliferation of mesangial cells.
目的：探讨容量调控氯通道在人胃癌细胞增殖中的作用。
AIM: To study the role of volume regulated chloride channel in the proliferation of human gastric carcinoma cells.
容积敏感氯通道是细胞膜上调节细胞容积和稳定膜电位的通道。
Volume sensitive chloride channel regulates cell volume and stabilizes membrane potential in cell membrane.
目的观察氯通道阻断剂对小鼠心室肌容积敏感性氯通道的影响。
Objective To examine the effect of chloride blockers on volume-sensitive chloride channels in mouse cardiac ventricular myocytes.
氯通道对许多上皮组织的分泌作用很重要，但其结构和机制尚了解甚少。
Chloride channels are crucial for secretion in many epithelial tissues, but little has been known about their structures and mechanisms.
方法在离体培养的A549细胞上，用膜片钳全细胞模式记录氯通道电流。
Methods the chloride channel currents were recorded in cultured A549 cells by using the whole-cell mode of patch clamp techniques.
目的：探讨有效抑制氯通道ClC - 3表达对顺铂诱导人神经胶质瘤u251细胞损伤的影响。
Objective; To investigate the effect of suppression of chloride channel CLC-3 expression on the cell injury in human glioma U251 cells induced by cisplatin.
氯通道阻断剂atp和NPPB可逆性地抑制此电流，ATP的抑制作用在外向电流显著强于内向电流。
Chloride channel blockers, NPPB and ATP, inhibited the currents reversibly. Moreover, the inhibition of ATP on the outward currents was stronger than that on the inward currents.
目的探讨蛋白酪氨酸磷酸化在胚胎鼠主动脉平滑肌细胞系a10细胞容积调节性氯通道电流中的调控作用。
AIM To investigate the relationship between protein tyrosine phosphorylation and volume-regulated chloride channel currents in A10 vascular cells.
近年研究发现容积调控性氯通道与肿瘤细胞的增殖、侵袭、迁移、凋亡及多药耐药性等恶性生物学行为有关。
In recent years, it has been realized that volume-regulated chloride channels are closely associated with proliferation, invasion, migration, apoptosis and multi drug resistance of tumor cells.
方法采用急性分离的小鼠心室肌细胞，低渗溶液激活容积敏感性氯通道电流，膜片钳全细胞记录法记录电流。
Methods Isolated mouse cardiac ventricular myocytes were subjected to whole-cell patch-clamp to record the hypotonicity activated chloride channel currents.
目的：研究不同生长周期的鼻咽癌低分化上皮细胞(CNE - 2 Z)的迁移能力及氯通道在迁移过程中所起的作用。
AIM: To clarify the migration capability of nasopharyngeal carcinoma cells (CNE-2Z) at different stages of the cell cycle and the roles of chloride channels in cell migration.
结论：CNE-2Z细胞的迁移能力与其所在的生长周期密切相关，氯通道在各期CNE-2Z细胞的迁移过程中起着重要作用。
CONCLUSIONS: The migratory ability is associated with the cell cycle in CNE-2Z cells. Chloride channels play an important role in cell migration of CNE-2Z cells.
结论SARS冠状病毒S2蛋白能抑制A549细胞氯通道的功能活动，PKC和P38可能不参与S2蛋白对通道电流的抑制作用。
Conclusions S2-protein from SARS coronavirus inhibits the chloride channel function in A549 cells, and both PKC and P38 are not involved in mediating this modulation.
结论：氯通道阻断剂NPPB或NFA能够在一定程度上减轻氧化应激引起的C6细胞损伤，可能与调节细胞膜功能和下调CLIC 4蛋白表达有关。
CONCLUSION: the chloride channel blockers NPPB or NFA lessen the oxidative injury of C6 cells through modulating the function of membrane and down-regulating the protein expression of CLIC4.
氯甲苯噻嗪能激活钾离子通道，数十年前就用于治疗高血压。
Diazoxide is known to activate potassium channels and was used decades ago to treat high blood pressure.
氨氯地平是新型二氢吡啶类钙通道阻滞剂。
Amlodipine (ALDP) is a new kind of calcium channel blocker of dihydropyridine.
从以色列蝎子中提取出多肽物氯毒素是特异性离子通道阻滞剂，能特异性与胶质瘤细胞表面的氯离子通道结合，进而杀死肿瘤细胞。
Catilan extracted from Leiurus quinquestriatus is a specific ion channel blocker. It can specifically bind chloride channels of glioma cells and kill these tumor cells.
结论：氨氯地平除具有L -型钙通道阻滞剂的特性外，还具有非l -型钙通道阻滞剂相关的多效性。
CONCLUSION: Amlodipine not only has the characteristic of L-type calcium antagonist but also has pleiotropic effects of non-L-type calcium antagonist.
结论：氨氯地平除具有L -型钙通道阻滞剂的特性外，还具有非l -型钙通道阻滞剂相关的多效性。
CONCLUSION: Amlodipine not only has the characteristic of L-type calcium antagonist but also has pleiotropic effects of non-L-type calcium antagonist.
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