本发明涉及氨基吡唑衍生物、其制备方法、及含有其的用于预防或治 疗缺血性疾病的组合物。
The present invention relates to aminopyrazole derivatives, a process for the preparation thereof, and a composition for preventing or treating an ischemic disease containing the same.
方法原甲酸三乙酯与氰乙酸乙酯缩合，然后和羟乙基肼经环合、水解等一锅法合成5-氨基吡唑-4-甲酸，然后在亚硫酸钠存在条件下加热脱羧得到5-氨基-1-羟乙基吡唑。
METHODS 5-amino-1-hydroxyethyl pyrazole-4-carboylic acid was synthesized through condensation of ethyl cyanoacetate and triethyl orthoformate followed by one-pot methodology of cyclization, hydolysis.
改进了重要中间体4氨基1甲基3 正丙基吡唑5酰胺（6 ）的合成工艺。
The method of preparation of the key intermediate, 4 amino 1 methyl 3 n propylpyrazole 5 carboxamide(6)was improved.
合成了一种新型铁络合偶氮染料，其母体染料由间氨基对羟基苯酚对磺酸和1-间氯苯-3-甲基吡唑啉酮偶合而成。
A new Fe-azo complex dyestuff was synthesized by complexing iron salt with the pre-dyestuff that was prepared from the o-aminophenolsulfonic acid and Cl-substituted pyrazolone.
合成了一种新型铁络合偶氮染料，其母体染料由间氨基对羟基苯酚对磺酸和1-间氯苯-3-甲基吡唑啉酮偶合而成。
A new Fe-azo complex dyestuff was synthesized by complexing iron salt with the pre-dyestuff that was prepared from the o-aminophenolsulfonic acid and Cl-substituted pyrazolone.
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