随着氟喹诺酮类抗菌药在临床广泛应用，肠球菌对其耐药性迅速增长。
Increasing resistance to FQs in enterococci has been noted with these agents broadly used in clinical medicine.
肠球菌对氟喹诺酮类抗菌药的耐药机制主要为靶位改变和药物主动外排导致的细胞内药物积聚减少。
The main two mechanisms of FQs resistance in enterococci are alterations in the targets of FQs and decreased intra-cellular drugs accumulation resulting from active excretion of drug.
目的：探讨氟喹诺酮类抗菌药后效应及其合理应用。
OBJECTIVE:To probe into the after-effects and rational use of fluroquinoloncs.
我们需要预防性给予抗生素药物，包括合理的药物和给药途径，建议在手术前开始频繁使用第四代氟喹诺酮类抗生素眼药水滴眼。
We need to provide antibiotic prophylaxis with an appropriate agent and administration regimen. We recommend a fourth-generation fluoroquinolone started with frequent dosing before surgery.
而许多临床常用的药物，如呋拉茶碱、氟伏沙明，喹诺酮类抗生素、维拉帕米、西米替丁和口服避孕药等，可抑制CYP1A2的活性。
On the other hand, many commonly used drugs, including furafylline, fluvoxamine, quinolone antibacterial, agents verapamil, cimetidine and oral contraceptives, can inhibit CYP1A2 activity.
目的合成喹诺酮类抗菌药中间体四氟邻苯二甲酸，并改进工艺，使之适用于工业化生产。
Objective To improve the synthesis of tetrafluorophthalic acid as an intermediate in preparing quinolone antibacterials.
目的合成喹诺酮类抗菌药中间体四氟邻苯二甲酸，并改进工艺，使之适用于工业化生产。
Objective To improve the synthesis of tetrafluorophthalic acid as an intermediate in preparing quinolone antibacterials.
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