这些发现提供了更多证据，表明了在可食用动物身上使用氟喹诺酮类药物会带来哪些问题。
The findings add to the growing body of evidence suggestive of the problems of using fluoroquinolonones in food-producing animals.
目的是探讨外排泵在嗜麦芽窄食单胞菌中对氟喹诺酮类药物的耐药性中的作用。
The objective is to explore the role of efflux pump in drug resistance to fluoroquinolones in Stenotrophomonas maltophilia.
目的合成新型含氟喹诺酮类抗菌化合物。
Aim To synthesize new fluoroquinolone analogues as antibacterial compounds.
结论应高度重视氟喹诺酮类药物的不良反应。
CONCLUSION Attach the highly importance to ADRs of the fluoroquinolones.
这些特征将有助于氟喹诺酮类化合物的结构分析。
These characteristics can be used for future structure elucidation in studies of fluroquinolones and analogue compounds.
目的：探讨氟喹诺酮类抗菌药后效应及其合理应用。
OBJECTIVE:To probe into the after-effects and rational use of fluroquinoloncs.
使用抗生素，特别是使用氟喹诺酮类药物，是一个危险因素。
Antibiotic use, especially use of fluoroquinolones, is a risk factor.
CCCP等能量抑制剂可加强细菌对氟喹诺酮类药物的摄取量。
The energy resistance inhibiter, such as CCCP, can intensify bacterial ingestion to fluoroquinolone drugs.
随着氟喹诺酮类抗菌药在临床广泛应用，肠球菌对其耐药性迅速增长。
Increasing resistance to FQs in enterococci has been noted with these agents broadly used in clinical medicine.
结论：新氟喹诺酮类抗生素虽然不良反应轻微，但仍应监测其不良反应。
Conclusion: the adverse reactions of new fluoroquinolones should be monitored though they are minor.
结果：归纳总结出氟喹诺酮类药物的不良反应发生的一般规律和有关特征。
RESULTS: The general rule and characteristics of occurrence of adverse reactions resulted from quinolones have been summarized.
目的：综述新氟喹诺酮类抗生素的各种不良反应，为临床合理用药提供依据。
Objective: to review various adverse reactions of new fluoroquinolones in order to provide the basis for clinical rational drug use.
目的：探讨主动外排泵在嗜麦芽寡养单胞菌对氟喹诺酮类药物耐药中的作用。
Objective:To explore the role of efflux pump in drug resistance to fluoroquinolones in Stenotrophomonas maltophilia.
注意：不要以为氟喹诺酮类药物对假单胞菌都有相同的功效，因为这不是事实；
NOTES: do not assume that all fluoroquinolones have equal efficacy against Pseudomonas, because they don't;
结果氟喹诺酮类药物具有不错的市场应用前景，但需注意可能的不良反应及耐药性的发生。
Results the results indicate that fluoroquinolone had perfect market prospect, however, the possible adverse drug reactions and resistance should be paid much attention.
新的盒装预警和用药指南将加强预警信息已经出现在氟喹诺酮类系统性抗菌药物的产品标签中。
The new Boxed Warning and Medication Guide would strengthen warning information already included in product labeling for the fluoroquinolone class of systemic antimicrobial drugs.
肠球菌对氟喹诺酮类抗菌药的耐药机制主要为靶位改变和药物主动外排导致的细胞内药物积聚减少。
The main two mechanisms of FQs resistance in enterococci are alterations in the targets of FQs and decreased intra-cellular drugs accumulation resulting from active excretion of drug.
第三代喹诺酮类药物，即氟喹诺酮类药物，具有抗菌谱广、抗菌作用强、作用迅速、副作用少等优点。
F-quinolones, as the third generation of quinolones, have many advantages such as broad antimicrobial spectrum, strong and fast antimicrobial effects and a few side-effects.
那天，一个实验室技术人员正在测试从患有细菌性眼结膜炎的人眼睛上提取的样本。这些人用过氟喹诺酮类眼药水。
That day, a laboratory technician was testing specimens taken from the eyes of people with bacterial conjunctivitis who had been given an antibiotic eye drop containing fluoroquinolone.
本文简要回顾了部分氟喹酮类药物的PK/PD研究，并对莫西沙星等主要氟喹诺酮类药物PK/PD参数进行总结。
In this article, we review PK/PD investigation of fluoroquinolones, and give a summary of PK/PD parameter of moxifloxacin and some other fluoroquinolones.
我们需要预防性给予抗生素药物，包括合理的药物和给药途径，建议在手术前开始频繁使用第四代氟喹诺酮类抗生素眼药水滴眼。
We need to provide antibiotic prophylaxis with an appropriate agent and administration regimen. We recommend a fourth-generation fluoroquinolone started with frequent dosing before surgery.
目的：研究不同药物浓度、不同化学结构的氟喹诺酮类药物对突变选择窗(MSW)内筛选的大肠埃希菌耐药突变体的靶位耐药基因的影响。
OBJECTIVE To investigate the effect of drug concentration, drug structure of fluoroquinolones on the resistant gene of Escherichia coli mutants selected in the mutant selection window (MSW).
结果：引起ADR最多的药物为氟喹诺酮类，发生率最高的药物是左氧氟沙星；与合并用药有关的ADR占总例数的41。59%，以静脉给药方式为主；
RESULTS: Most of the ADR cases were induced by quinolones, with levofloxacin showing the highest proportion. 41.59% were induced by combined use of drugs, which were administered chiefly through IV.
而许多临床常用的药物，如呋拉茶碱、氟伏沙明，喹诺酮类抗生素、维拉帕米、西米替丁和口服避孕药等，可抑制CYP1A2的活性。
On the other hand, many commonly used drugs, including furafylline, fluvoxamine, quinolone antibacterial, agents verapamil, cimetidine and oral contraceptives, can inhibit CYP1A2 activity.
目的合成喹诺酮类抗菌药中间体四氟邻苯二甲酸，并改进工艺，使之适用于工业化生产。
Objective To improve the synthesis of tetrafluorophthalic acid as an intermediate in preparing quinolone antibacterials.
目的合成喹诺酮类抗菌药中间体四氟邻苯二甲酸，并改进工艺，使之适用于工业化生产。
Objective To improve the synthesis of tetrafluorophthalic acid as an intermediate in preparing quinolone antibacterials.
应用推荐