主题演讲将突出集成斑块脂质代谢和免疫活性的核激素受体的新兴角色。
The keynote address will highlight emerging roles of nuclear hormone receptors as integrators of plaque lipid metabolism and immune activity.
这些核激素受体由其配体(激活物)激活后，通过偶联特异的反应元件来调控多种靶基因的表达。
After activation by ligand as is the case with nuclear receptors, PPARs binds to a specific element in the promoter region of target genes.
我们惊奇地发现，在肺癌和正常肺脏组织中核激素受体的表达谱模式对肺癌患者预后判断是如此之精确。
We were amazed to find that the pattern of expression of nuclear receptors in both lung cancers and normal lung tissue were so predictive of a patient's outcome.
PPAR激动剂，是细胞核激素受体家族转录因子的一个成员，被广泛用来治疗II型糖尿病，而且相对无毒。
Agonists of PPAR, a member of the nuclear hormone receptor family of transcription factors, are widely used in the treatment of type II diabetes and are relatively non-toxic.
因为现在已经有如此之多的药物靶向这些核受体，我们下一步将设法筛选出那些药物具有杀灭表达这些特异性核激素受体肺癌细胞的作用。
Because available drugs already target so many of these receptors, our next step is to find out which drugs will kill lung cancer cells expressing these specific receptors.
目的构建人黑色素浓集激素1型受体（MCHR1）真核表达载体，转染CHO细胞，建立稳定转染的CHO细胞系。
Objective To construct eukaryotic expressing vector of human melanin-concentrating hormone receptor 1(MCHR1), then to transfect CHO cells with the vector for establishment of stable CHO cell line.
目的克隆人促甲状腺激素受体胞外段基因，构建重组真核表达质粒，获得具有免疫学活性的纯化重组蛋白。
Objective to clone and construct the plasmid containing human thyroid stimulating hormone receptor (TSHR) gene ectodomain, and then identify the immunoreactivity of the purified recombinant protein.
目的探讨核受体激素nr4a1在人卵巢周期中的表达和定位及其在卵泡发育中的调控机理。
Objective to investigate the expression of nuclear receptor subfamily 4, group a, member 1 (NR4A1) in human follicular cells during the ovarian cycle.
大多数雄激素非依赖性前列腺癌均高表达AR和核受体辅活化子、如转录中间因子2（TIF-2），ARA24、PIAS、类固醇受体辅活化子-1（SRC-1）等有力地支持了这个假说。
The "superactive AR"hypothesis was supported by the fact that the majority of AIPC expresses high level of AR and nuclear receptor(NR) coactivators, such as TIF-2, ARA24, PIAS, SRC-1.
研究结果提示，精索静脉曲张睾丸功能障碍可能与血清睾酮浓度低下及睾丸细胞核雄激素受体反应异常有关。
The authors suggest that the disturbed function of testes in rats with varicocele may be related to lower values of serum testosterone and abnormal reaction of NAR in testes.
在心肌细胞中，T3结合到细胞核中的甲状腺激素受体，其依次结合靶基因调节区中的甲状腺激素反应元件以调节转录。
In the cardiomyocyte, T3 binds to thyroid hormone receptors in the nucleus, which in turn bind to thyroid hormone response elements in the regulatory regions of target genes to regulate transcription.
在心肌细胞中，T3结合到细胞核中的甲状腺激素受体，其依次结合靶基因调节区中的甲状腺激素反应元件以调节转录。
In the cardiomyocyte, T3 binds to thyroid hormone receptors in the nucleus, which in turn bind to thyroid hormone response elements in the regulatory regions of target genes to regulate transcription.
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