人们很早就注意到，真核细胞中核小体核心组蛋白N-端尾部的乙酰化水平与基因活化密切相关。
It has been known for some time that the acetylation of N-termini of core histones in nucleosome is associated with gene activation.
真核细胞中，核小体是染色质的基本单位，它由两个拷贝HA、HB、H和H所组成的核心组蛋白八聚体，及缠绕于其上的bpDNA构成。
In eukaryotic cells, the fundamental unit of chromatin is nucleosome, which is composed of a histone octamer with two copies of HA, HB, H and H and base pairs of DNA.
组蛋白 H3与H2A，H2B，H4 共同构成了真核生物核小体的八聚体核心。
Histone H3 along with H2A, H2B, and H4 form the eukaryotic nucleosome octamer core.
组蛋白是染色质的核心，其尾部共价修饰在基因表达调控中有重要作用。
Histone is the core of chromatin, and covalent modification of histone tails have fundamental roles in regulation of gene expression.
细胞周期调控机制的核心是一组蛋白激酶。
The core of cell cycle regulation and control mechanism are relative to a group of protein kinase.
核心过程的表观遗传的产业包括DNA甲基化、组蛋白改性、核小体重建、核染色质动力学和互动子都存在。
Core processes of epigenetic inheritance include DNA methylation, histone modification, nucleosome remodeling, nuclear dynamics and chromatin interaction with non-coding RNAs.
组蛋白H3与其他类型的组蛋白分子H2A，H2B，H4共同构成了真核生物核小体的八聚体核心。
Histone H3 is one of the four histones, along with H2A, H2B, and H4, which form the eukaryotic nucleosome octamer core.
在一起形成核小体核心的组蛋白。
Histones that come together to form the core of the nucleosome.
组蛋白是染色质的核心，其尾部的共价修饰组成组蛋白密码，调节许多生物学事件。
Histone is the nucleus of chromatin, the covalent modifications in its tails form the histone codes that regulate a number of biological processes.
核小体核心由140个碱基对的DNA围绕一个组蛋白小球组成，每一个组蛋白小球包含两个H_2A、H_2B、H3和H4的四聚体分子。
The core consists of 140 base pair of DNA wrapped around a globular histone bead containing two each of histones H2A, H2B, H3 and H4.
当研究人员向突变细胞内加入人造泛素——一种组蛋白复合物后，细胞恢复正常，表明这的确是Brca1基因的核心功能。
When the researchers added artificial ubiquitin-histone complexes to the mutant cells, the cells recovered, suggesting this was indeed the Brca1 gene's core function.
当研究人员向突变细胞内加入人造泛素——一种组蛋白复合物后，细胞恢复正常，表明这的确是Brca1基因的核心功能。
When the researchers added artificial ubiquitin-histone complexes to the mutant cells, the cells recovered, suggesting this was indeed the Brca1 gene's core function.
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