本研究旨在对BRD7的核定位信号进行预测、结构分析和功能鉴定，并考察其对BRD7亚细胞定位的影响。
Objective: To structurally analyse and functionally identify the nuclear localization signal (NLS) in BRD7 and then study its effect on the subcellular localization of BRD7.
目的寻找与人巨细胞病毒（HCMV）PPUL44蛋白核定位信号（NLS）具有较强结合能力的多肽，研究这些多肽的氨基酸序列特点。
Objective To find the peptides that have strong binding ability to the nuclear localization signals (NLS) of human Cytomegalovirus (HCMV) PPUL44 protein, and to analyze their amino acid sequences.
结论：BRD7的65 ~ 96位氨基酸残基为BRD7功能性核定位信号所在区域，在BRD7胞核分布模式中发挥了十分重要的作用。
Conclusion: The amino acid region from 65 to 96 is a functional NLS in BRD7 and it is an essential motif affecting BRD7 nuclear distribution.
核定位序列（NLS）是信号蛋白分子上与入核转运相关的氨基酸序列。
Nuclear localization sequence(NLS) is the specific amino acid sequence on the signaling proteins to be sufficient for their nuclear translocation.
核定位序列（NLS）是信号蛋白分子上与入核转运相关的氨基酸序列。
Nuclear localization sequence(NLS) is the specific amino acid sequence on the signaling proteins to be sufficient for their nuclear translocation.
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