属于核受体超家族成员，是一个孤儿受体。
GCNF (Germ Cell nuclear Factor) is a member of nuclear receptor superfamily and also an orphan receptor.
国际肝病：核受体在胆汁淤积性肝病很重要。
Hepatology Digest: The nuclear receptors are important in cholestatic liver disease.
结合了CPA的AR可与核受体协同抑制因子作用。
核受体是配体活化的转录因子，能调控大量的靶基因。
Nuclear receptors (NRs) are ligand-activated transcription factors that regulate the activation of a variety of important target genes.
本文简要地介绍了核受体在调节脂质代谢方面的研究进展。
This paper briefly reviews the researches on the regulation of lipid metabolism by nuclear receptors.
近年来核受体调节脂质代谢的研究已成为国内外研究的热点。
Recently, studies focusing on the regulation of lipid metabolism by nuclear receptors have gained increasing attention home and abroad.
本文对近期所了解的细胞核受体调节转录的分子机制进行综述。
This review addresses recent advances in our understanding of the molecular mechanisms regulating transcription of these nuclear receptors.
背景肝x受体是一种核受体，与细胞内胆固醇及糖等能量代谢有关。
Background Liver X receptors (LXRs) are members of the nuclear hormone receptor superfamily which involve in energy metabolism of intracellular cholesterol and glucose regulation.
研究表明，核受体的磷酸化与去磷酸化在多条信号途径中起着重要作用。
It is demonstrated that phosphorylation and dephosphorylation of NRs play a critical role in a variety of signaling pathways.
核受体可单独或相互联系而发挥作用，亦可与其他转录因子进行交互通话。
Nuclear receptors can act alone or interact on each other, and they can also crosstalk with other transcriptional factors.
最近的研究显示了核受体在调节脂质和碳水化合物代谢、纤维化和炎症中的重要作用。
Recent studies indicate an important role for nuclear receptors in regulating lipid and carbohydrate metabolism, fibrosis and inflammation.
因此，深入研究核受体及其配体的作用将为慢性气道炎症性疾病展现广阔的治疗前景。
Therefore, further investigation of nuclear receptors and their ligands may reveal a novel potential therapeutic prospect for chronic airway inflammation.
目的探讨核受体激素nr4a1在人卵巢周期中的表达和定位及其在卵泡发育中的调控机理。
Objective to investigate the expression of nuclear receptor subfamily 4, group a, member 1 (NR4A1) in human follicular cells during the ovarian cycle.
HR蛋白是细胞核受体辅阻遏物的发现证明HR蛋白是通过在毛发周期中调节基因表达来发挥作用的。
The discovery that the HR protein is a nuclear receptor corepressor indicated that HR function in hair cycling is by regulating gene expression.
由于核受体在调节脂质代谢、糖代谢以及炎症反应方面发挥重要作用，它们是治疗心血管疾病理想的靶标。
As NRs play major roles in the regulation of lipid metabolism, glucose homeostasis, and inflammatory processes, they are considered as ideal targets for the treatment of cardiovascular diseases.
PR在神经细胞核中的定位表明其为核受体，很有可能在基因水平上参与拟穴青蟹视神经节的生理活动调节。
PR is a nuclear receptor which may mediate the physiological activities of optic ganglia via nuclear receptor in gene level.
核受体家族的经典作用机制是在其配基存在下结合在靶基因的应答元件上，从而在转录水平上调节基因的表达。
The classical mechanism for nuclear receptors to regulate gene expression is to bind the hormone response element(HRE) on the target gene in the presence of their ligands.
结果该质粒有正确的阅读框，其表达蛋白不具有自主转录激活作用，与已知核受体辅活化子PNRC有明显的相互作用。
Results The protein expressed by the plasmid which had a correct reading frame, had no transcriptional activation and could interact with a known coactivator PNRC.
法尼酯x受体(FXR)是代谢性核受体超家族中的一员，在调节胆汁及脂类等物质代谢、维持内环境的稳定方面发挥着重要作用。
Farnesoid X receptor (FXR), a member of the metabolic nuclear receptor superfamily, plays key roles in maintaining bile acid and lipid homeostasis.
因为现在已经有如此之多的药物靶向这些核受体，我们下一步将设法筛选出那些药物具有杀灭表达这些特异性核激素受体肺癌细胞的作用。
Because available drugs already target so many of these receptors, our next step is to find out which drugs will kill lung cancer cells expressing these specific receptors.
大多数雄激素非依赖性前列腺癌均高表达AR和核受体辅活化子、如转录中间因子2（TIF-2），ARA24、PIAS、类固醇受体辅活化子-1（SRC-1）等有力地支持了这个假说。
The "superactive AR"hypothesis was supported by the fact that the majority of AIPC expresses high level of AR and nuclear receptor(NR) coactivators, such as TIF-2, ARA24, PIAS, SRC-1.
主题演讲将突出集成斑块脂质代谢和免疫活性的核激素受体的新兴角色。
The keynote address will highlight emerging roles of nuclear hormone receptors as integrators of plaque lipid metabolism and immune activity.
我们惊奇地发现，在肺癌和正常肺脏组织中核激素受体的表达谱模式对肺癌患者预后判断是如此之精确。
We were amazed to find that the pattern of expression of nuclear receptors in both lung cancers and normal lung tissue were so predictive of a patient's outcome.
细胞表面的受体对外界信息的相应反应就是将信息以信号的形式传递给启动基因表达和控制细胞功能的细胞核。
In response to such incoming information, receptors on a cell's surface send signals to the nucleus that tweak gene expression and control cellular function.
目的：研究表皮生长因子受体和增殖细胞核抗原在胃肿瘤中的表达及其临床意义。
Objective: To study the expression of EGFR and PCNA protein in human gastric neoplasm and its clinical significance.
PPAR激动剂，是细胞核激素受体家族转录因子的一个成员，被广泛用来治疗II型糖尿病，而且相对无毒。
Agonists of PPAR, a member of the nuclear hormone receptor family of transcription factors, are widely used in the treatment of type II diabetes and are relatively non-toxic.
疑核内含有大量的神经递质，如乙酰胆碱，生物胺，神经肽，氨基酸等及其受体。
NA contains a great variety of neurotransmitters including acetylcholine, biogenic amines, neuropeptides and amino acids, and their receptors.
结论：褪黑色素可通过作用于外侧缰核的阿片受体而影响其痛相关神经元对痛刺激的反应，这可能是褪黑色素中枢镇痛机制之一。
Conclusion: Melatonin can change the responses of pain neurons to pain stimulation via opioid receptor in the LHb, which might be one of analgesic mechanisms by MEL.
目的构建人胃动素受体基因的原核表达载体。
Objective to construct expression plasmid of human motilin receptor.
目的构建人胃动素受体基因的原核表达载体。
Objective to construct expression plasmid of human motilin receptor.
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