未发现研究对象染色体结构异常。
结果：146例外周血染色体异常核型中常染色体数目异常占4.8％（7/146）； 常染色体结构异常占29.5％（43/146）；
Results: In 146 cases of chromosomes aberrance, the rate of abnormal eu-chromosome number and abnormal euchromosome structure was 4. 8% (7/146) and 29. 5% (43/146).
有两个着丝粒的结构异常的染色体。
Dicentric — a structurally abnormal chromosome with two centromeres.
结论FISH是一种在分析CLL染色体数目和结构异常方面较为快速、准确和敏感的方法，可为CLL的研究提供较为准确的分子遗传学信息。
Conclusion FISH is a more rapid, accurate and sensitive technique in analysis of chromosome aberrations in CLL. FISH may provide accurate information of molecular cytogenetics for CLL.
染色体结构改变造成遗传物质的重新排列。若为非平衡型重排，则可导致异常表型。
Rearrangement — Chromosome breakage followed by reconstitution in an abnormal combination. If unbalanced, the rearrangement can produce an abnormal phenotype.
允许早期发现异常仔细评估染色体的结构缺陷和可能的基础上有针对性。
Abnormal findings allow for early careful evaluation of chromosomes and possible structural defects on a targeted basis.
允许早期发现异常仔细评估染色体的结构缺陷和可能的基础上有针对性。
Abnormal findings allow for early careful evaluation of chromosomes and possible structural defects on a targeted basis.
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