杂合性丢失是基因一个拷贝的正常功能丢失，同时另一个拷贝已经失活。

LOH is usually defined as the loss of normalfunction of one copy of a gene in which the other copy was already inactivated.

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目的：探讨头颈部鳞癌的微卫星不稳定性(msi)及杂合性丢失(LOH)。

AIM: To examine the microsatellite instability (MSI) and loss of heterozygosity (LOH) in head and neck squamous cell carcinomas (HNSCC).

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结果25例患者中，有17例存在一个或多个位点的杂合性丢失，占68.0%。

Results Of the 25 cases, 17 (68.0%) showed LOH at one or more loci.

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结果25例患者中，有17例存在一个或多个位点的杂合性丢失，占68.0%。

Results Of the 25 cases, 17 (68.0%) showed LOH at one or more loci.

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