最新的观点倾向于最大限度抑制靶点的最小剂量。
Latest opinions tend to favor the minimum dose that maximally inhibits the target.
应用激素时,应最小剂量。(证据级别和推荐等级,3C)。
When corticosteroids are prescribed, this should be at the lowest possible dose (level of evidence and strength of recommendation, 3 c).
但什么是这些药物的最佳剂量,最大耐受剂量,最大限度抑制目标的最小剂量?
The maximum tolerated dose? The minimum dose that leads to maximum inhibition of the target?
采用多巴酚丁胺(DB)、去甲肾上腺素(NE)及两者最小剂量联合应用以纠正血压。
Dobutamine (DB), norepinephrine (ne) and combination of DB and ne were used in the lowest dose.
根据测试小组的论据,多酚物质要能够维持抗癌作用的最小剂量,相当于每天要饮用一瓶红酒的含量。
According to the authors, the amount of polyphenols necessary to obtain an anti-cancer effect is the equivalent of drinking about a bottle of red wine each day.
结论:在激素的应用上应本着个体化的原则,尽可能地采用只要能达到所期望的疗效的最小剂量,以减少不良反应的发生。
CONCLUSION: the use of hormone should adhere to individualized principle and adopt the minimum dosage with expected therapeutic efficacy to reduce the occurrence of adverse reactions.
但是这些“天然”的辐射量在经常改变,因此我们很难选择一个数目作为限制量,而最好的辐射量限制也许说为“最小剂量”可能更合适。
The difficult thing with this 'natural' dose is that it is continuously changing. It is therefor impossible to choose a set number as a limit. The limit is better formulated as 'as small as possible'.
雄蛾性附腺提取物对雌蛾性信息素合成的抑制作用与注射剂量有明显的相关性,02ME (雄蛾当量)是产生显著抑制作用的最小剂量。
There was a dose response relationship of pheromonostatic activity of male accessory gland extract, and 0 2ME (male equivalent) was the minimum dose required for effective inhibition.
雄蛾性附腺提取物对雌蛾性信息素合成的抑制作用与注射剂量有明显的相关性,02ME (雄蛾当量)是产生显著抑制作用的最小剂量。
There was a dose response relationship of pheromonostatic activity of male accessory gland extract, and 0 2ME (male equivalent) was the minimum dose required for effective inhibition.
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