前病毒整合位点、靶细胞特性和整合后的载体结构与转入基因表达的稳定性紧密相关。
The integration sites of provirus, the nature of the target cells and the structure of vectors were closely related to the stability of gene expression.
目的：为分析慢病毒介导的转基因小鼠中外源基因整合位点的信息，应用反向PCR克隆整合位点序列。
Objective: To investigate the information of transgene integrations in mice mediated with lentiviral vectors, the inverse PCR was used to clone the sequences of integration sites.
通过慢病毒整合位点鉴别，我们得以分辨转移和非转移瘤并明确可区分这两种不同类型肿瘤的基因表达改变。
Identification of the lentiviral integration sites allowed us to distinguish metastatic from non-metastatic tumours and determine the gene expression alterations that distinguish these tumour types.
结论证实了转基因动物导入外源性基因整合位点是随机的；整合位点引起的肿瘤可以随着细胞发育的不同阶段，逐渐的显现。
It is proved that the conformity site of exogenous gene in APP transgenic mice is random, the tumor induced by gene conformity site could manifest with different stage of cell growing.
在某些卵里基因物质在随意位点与染色体整合而成为老鼠细胞的遗传物质。
In some of the eggs, the genetic material integrates at a random site on a chromosome and so becomes part of the mouse cell's genetic material.
进行哮喘相关研究的整合分析研究，并提供每个位点/位基因识别可靠度的网页注解来源。
Perform a meta-analysis of studies of asthma association studies and provide a web-annotated resource of the reliability of each locus/ allele identified.
进行哮喘相关研究的整合分析研究，并提供每个位点/位基因识别可靠度的网页注解来源。
Perform a meta-analysis of studies of asthma association studies and provide a web-annotated resource of the reliability of each locus/ allele identified.
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