结论:获得一株具有宫颈癌抗原内影像的抗独特型单克隆抗体。
CONCLUSION: a monoclonal anti-idiotypic antibody with an "internal image" of cervical cancer antigen was obtained.
目的:制备宫颈癌抗独特型单克隆抗体并鉴定其抗原模拟特性。
AIM: To produce monoclonal anti-idiotypic antibody against uterine cervical cancer and identify its antigenic mimicry properties.
汪静。李官成。童永清鼻咽癌人源抗独特型基因工程抗体的原核表达及鉴定。
Wang J. Li GC Expression, purification and identification of the human anti-idiotypic single chain antibodies against nasopharyngeal carcinoma in E. coli.
目的用模拟人卵巢癌抗原并有满意免疫原性的抗独特型微抗体进行临床前动物实验研究。
An anti-idiotypic mini body with optimal antigenicity which mimicking ovarian cancer antigen was used for therapeutic research in mice model bearing ovarian cancer.
但由于目前所使用的抗独特型抗体多为鼠源性,用于人体可产生人抗鼠抗体反应,从而影响疗效。
But at present, many anti idiotypic antibodies are mouse original antibodies, which can cause human anti mouse antibody (HAMA) response and decrease the curative effect.
为了降低人抗鼠抗体反应,获得满意的免疫原性,将模拟人卵巢癌抗原的抗独特型单链抗体人源化。
In order to reduce the human anti mouse antibody response and obtain optimal antigenicity, anti idiotype single chain which mimicking ovarian cancer antigen has been humanized.
目的探讨卵巢上皮性癌6B11抗独特型微抗体(6B11微抗体)的最佳免疫剂量和免疫间隔时间,为用于临床治疗卵巢上皮性癌打下基础。
Objective To probe better immunization dose and interval of anti-idiotypical minibody (6B11 minibody) in animals and to guide the clinical trials of ovarian epithelial cancer treatment.
实验还证明,24个抗DNA单抗中有15个与H241不同程度地存在独特型交叉反应。
The experiments also demonstrated that 15 of 24 other monoclonal anti-DNA antibodies represented idiotypic cross-reactivity with H241 in different degrees.
实验还证明,24个抗DNA单抗中有15个与H241不同程度地存在独特型交叉反应。
The experiments also demonstrated that 15 of 24 other monoclonal anti-DNA antibodies represented idiotypic cross-reactivity with H241 in different degrees.
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