内皮以抑素能抑制裸鼠皮下移植瘤的生长(P<0.05);
Endostatin significantly suppressed the growth of the implanted tumor in nude mice (P< 0. 05).
内皮抑素是一种抗血管生成的抑制因子,它特异性地作用于新生微血管的内皮细胞,其水平与肿瘤血管生成有着明显的相关性。
Endostatin is a kind of angiogenesis inhibitor, specific effecting in the new microvascular endothelial cells. The level of endostatin and the angiogenesis of tumor have a close correlation.
生长抑素或生长抑素类似物可通过SSTR2抑制肿瘤细胞的增生。
Many studies have demonstrated tumor cell growth inhibition by somatostatin and somatostatin analogs in SSTR2-positive tumors.
目的探讨反义vegf基因和内皮抑素基因联合转染在抑制肿瘤血管生成和肿瘤生长转移中的作用。
Objective to explore the co operative inhibitory effect of antisense VEGF gene and endostatin gene transfection on tumor angiogenesis, tumor growth and metastasis of lung cancer.
结果人血管抑素基因可明显的抑制卵巢癌裸鼠移植瘤生长。
Results Human angiostatin gene could suppress the growth of transplanted tumor from ovarian neoplasm nude mice obviously.
目的研究携带血管抑素K1-5基因的腺病毒载体对其对血管内皮细胞增殖的抑制作用。
Objective To investigate the suppression effects of a adenovirus vector containing angiostatin K1-5 gene to the proliferation and migration of vascular endothelial cells.
目的:内皮抑素是一种特异性血管内皮生长抑制因子,本研究目的在于探讨人内皮抑素对卵巢癌skov3细胞生长的抑制作用及其机制。
In this study, we aim to evaluate the inhibitory effect of endostatin on SKOV3 cell and to investigate the possible mechanism of the inhibition.
方法建立人卵巢癌裸鼠动物模型,检测腺病毒介导的人血管抑素基因对肿瘤生长的抑制作用。
Methods A human ovarian cancer model using a nude mice was built to test the suppressive effect of human angiostatin gene mediated by adenovirus on the tumor growth.
生长抑素(SS)通过抑制垂体生长激素的分泌而影响机体的生长性能,SS同时也能抑制钙蛋白酶的表达和活性。
Somatostatin (SS) is the major inhibitory factor for growth hormone secretion and has also been reported to attenuate the expression and activity of calpains.
内皮抑素是一种新的能强烈抑制血管形成的抑制因子,内皮抑素水平与肿瘤具有明显的相关性,其水平可以作为肿瘤的临床预后指标。
Endostatin is a new inhibitor factor which can intensively inhibit angiogenesis. The level of endostatin is significantly related to tumor, which can be a prognostic indicator of tumor.
某些含有此药物的处方比不含抑肿瘤抗生素之处方,较具有抑制肿瘤的疗效。然而,其对病患存活的好处则尚未获得确认。
Some of these agents have demonstrated higher tumour response rates than non-anti tumour antibiotic regimens, however a survival benefit has not been established in this setting.
大量研究表明生长抑素及其类似物具有抗肿瘤活性,能抑制内分泌肿瘤的增殖,且表现出对许多实体肿瘤,尤其是消化系统肿瘤有抑制作用。
A lot of research - es indicate the anticancer activity of somatostatin analogue. It was reported to suppress proliferation of endocrine tumors, especially some solid tumors in digestive system.
生长抑素是生长激素释放的抑制因子,是一种神经活性肽,广泛分布于中枢神经系统和周围组织,包括眼组织。
Somatostatin released by growth hormone is an inhibiting factor and active nervous peptide, and it is mainly distributed in center nerve system, peripheral tissue and ocular tissue.
研究血管抑素基因联合化疗药物顺铂对人卵巢癌细胞SKOV3诱导的裸鼠腹腔肿瘤和腹水的抑制作用及其相关机理。
To observe the effects of angiostatin gene therapy combined with chemotherapy on intraperitoneal tumor and ascites fluid induced by human ovarian epithelial carcinoma cell line SKOV3 in nude mouse.
目的研究血管抑素对胃癌生长和转移的抑制作用。
Objective To study the effects of angiostatin on the growth and metastasis of gastric cancer in vivo.
通过建立荷人胃癌的裸鼠动物模型,分析基因转导后动物肿瘤细胞中内皮抑素的表达情况及对肿瘤的抑制作用。
Animal model of gastric cancer bearing nude mice were established to assay the expression of mouse endostatin and inhibition for tumor cell in vivo.
胰抑素是近年来新发现的一个具有抑制胰岛素分泌作用的多肽,广泛分布于神经组织和内分泌系统中。
Pancreastatin, a newly discovered 49-residue peptide, has been found to be capable of inhibiting insulin secretion, and widely distributed in the nervous tissue and endocrine system.
本文综述了肌肉生长抑制素蛋白的结构、活性调控、信号转导途径以及肌抑素基因的表达和生物学作用。
In this paper the formation, activity regulation and signal transduction pathway of myostatin were reviewed. At the same time, the gene expression and biological effect of myostatin were discussed.
结论重组内皮抑素可有效抑制CNV生长,为临床防治CNV提供了一种新的方法。
Conclusion Recombinant endostain can effectively inhibit the growth of CNV, which provides a new method for the prevention and treatment of this condition.
结论低分子肝素化内皮抑素可有效抑制角膜新生血管的生长,效果优于内皮抑素。
Conclusions LMWHES can effectively inhibit the growth of CNV and is superior to ES.
结果表明,内抑素基因可在骨骼肌或肿瘤内表达,并显著抑制肿瘤生长。
Tumor growth was significantly inhibited by intramuscular or intratumoral endostatin gene administration which indicated…
结果表明,内抑素基因可在骨骼肌或肿瘤内表达,并显著抑制肿瘤生长。
Tumor growth was significantly inhibited by intramuscular or intratumoral endostatin gene administration which indicated…
应用推荐