目的：介绍环氧酶- 2抑制剂药物的临床应用进展，以期为临床医师、药师提供参考。
OBJECTIVE: to introduce the progress in the clinical application of epoxidase-2 inhibitors for references of clinician and pharmacists.
目的探讨选择性及非选择性环氧合酶-2抑制剂（COX-2）对体外培养的结肠癌细胞生长的影响及其作用的信号传导通路。
Objective To evaluate the inhibiting effect of selective and non-selective cyclo-oxygenase-2(COX-2) inhibitor on growth of colon cancer cell lines in vitro and its signal transduction pathway.
为了观察坐骨神经损伤(SNI)后小鼠全脑环氧合酶(COX) -1和COX - 2的表达变化，以及不同选择性的COX抑制剂对SNI所致神经病理性痛的效应。
To observe the expression of cyclooxygenase (COX) -1 and COX-2 in brain after spared nerve injury (SNI) and compare the analgesic effects of COX inhibitors with different selectivity.
目的观察环氧酶抑制剂对胆囊切除术后创伤性应激反应的影响。
Objective To study the effect of cyclo-oxygenase inhibitor (indocontin) on traumatic stress response of patients undergoing cholecystectomy.
目的探讨环氧酶抑制剂对脓毒症时代谢反应的影响。
Objective to observe the effect of cyclooxygenase inhibitor on septic metabolism.
本论文综述了环氧酶抑制剂的作用机理、选择性的COX-2抑制剂的研究进展以及COX-2抑制剂T614的研究情况。
The mechanism of the COX inhibitors, development of the selective COX-2 inhibitors and the studies on T614 were briefly reviewed.
环氧合酶- 2 (COX - 2)抑制剂因其广泛的预防和抑制肿瘤作用，近年来得到人们的关注。
Cyclooxygenase-2 (COX-2) inhibitors has recently received extensive attention for its role in prevention and inhibition of malignancies.
当ABA的合成被去甲二氢愈创木酸（NDGA），ABA合成酶9-顺式-环氧类胡萝卜素双加氧酶的抑制因子所抑制，水稻种子萌发无影响。
When ABA biosynthesis was inhibited by nordihydroguaiaretic acid (NDGA), an inhibitor of the ABA anabolic enzyme 9-cis-epoxycarotenoid dioxygenase (NCED), rice seed germination showed no response.
目的：探讨选择性环氧舍酶-2抑制剂塞来昔布对大鼠胃肿瘤发生的预防作用。
OBJECTIVE: to investigate the preventive effect of celecoxib, a selective cyclooxygenase (cox) - 2 inhibitor, on stomach tumor in rats.
以对甲苯乙酮和三氟醋酸乙酯为原料，经缩合、环合两步反应得到2型环氧酶抑制剂赛来昔布，总收率为6 7%。
Celecoxib as a cyclooxygenase-2 inhibitor, was synthesized from p-methylacetophenone and ethyl trifluoroacetate by successively condensation and cyclization in 67% overall yield.
当患者需氧抗炎镇痛治疗会有高风险的复发性溃疡出血，应该接受环氧化酶-2（COX-2）抑制剂和质子泵抑制剂的联合治疗。
Patients at very high risk for recurrent ulcer bleeding who need anti-inflammatory analgesics should receive combination treatment with a COX 2 inhibitor and a PPI.
当患者需氧抗炎镇痛治疗会有高风险的复发性溃疡出血，应该接受环氧化酶-2（COX-2）抑制剂和质子泵抑制剂的联合治疗。
Patients at very high risk for recurrent ulcer bleeding who need anti-inflammatory analgesics should receive combination treatment with a COX 2 inhibitor and a PPI.
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