目的:研究药动学房室模型的辨识问题。
OBJECTIVE: To study the identification problems of pharmacokinetic compartment models.
用非房室模型参数估算法计算药动学参数。
The pharmacokinetic parameters were calculated according to non - compartment model.
由非房室和房室模型评价药物动力学参数。
Pharmacokinetic parameters were assessed with noncompartment model and model-dependent method.
作者借助于线性系统理论讨论了乳突型N房室模型的参数辨识方法。
The Method for identifying the parameter of mammillary N-compartment model is discussed in this paper on the basis of linear system theory.
试验所得的血浆浓度时间数据采用非房室模型统计矩原理分析处理。
Plasma concentration time data derived from the experiment were analyzed by non compartmental methods based on statistical moment theory.
PCNONLIN程序进行药物动力学房室模型数据拟合和参数计算;
The modelling data were performed with a compartment pharmacokinetic modelling program (PCNONLIN).
药物浓度对时间数据作房室模型和统计矩解析,并求出相应的药动学参数。
Analysis of the data was executed by compartmental model and statistical moment calculation from which pharmacokinetic parameters were obtained.
用二房室模型比较了原位灌流的大鼠空肠和迴肠锌吸收速率常数及动态过程。
The kinetics of zinc absorption of jejunum and that of ileum were compared in perfused rats by a two-compartmental model.
大鼠灌胃隐丹参酮和丹参酮提取物后的药-时曲线分别符合一房室和二房室模型。
The plasma concentration-time curves of cryptotanshinone were best fitted with one-compartment and two-compartment models for cryptotanshinone and tanshinones extract of Salvia miltiorrhiza Bge.
该模型综合了生理药动学模型和房室模型的优点,并提出了血药浓度衰减的频率因子。
It has the advantage of physiological pharmacokinetics model, its kinetic parameters have anatomic and physiological meanings, and its solution can be expressed succinctly like the atrium model.
基于改进的单纯形算法和残数法,对药物动力学房室模型中的有关参数计算进行了研究。
By using improved simplex method and residuals method, a calculation based on the parameters of compartment model of pharmacokinetics is presented.
把人体对酒精的吸收、排放简化为一般的房室模型,提出了吸收因子、消除因子的概念。
In this article, the courses of absorption and excretion of alcohol through bodies is simplified to general house models, and the conceptions of absorption factor and excretion factor are defined.
方法采用LC-MS/MS法测定血浆中甲氯噻嗪的浓度并用非房室模型计算药动学参数。
The concentration of methyclothiazide in blood plasma was measured by an validated LC-MS/MS method and were assessed with non-compartment model to obtain the pharmacokinetic parameters.
本文讨论了确定药物剂量的二房室模型,在快速静脉注射给药方式下给出了各参数的估计。
In this paper, the two-compartment model of determining the Medicine dosage was discussed, and the parameter estimators were given on the condition of quick intravenous injection.
结果除桑菊饮呈一房室模型分布外,其他三方均属二房室模型分布,四个方剂基本上均按一级动力学消除。
The concentration, of all four prescriptions was eliminated as first-order kinetics, and their distribution appeared generally to be two-compartment model expect Sangju-Yin by this method.
目的:在大鼠心肌缺血模型上研究房室交界区(房室结及房室束)的形态学变化。
Objective: To study the morphological changes of atrioventricular junction area (atrioventricular node and atrioventricular bundle) on the myocardial ischemia model of rat.
预防组、治疗组与模型组比较,恢复到一度房室传导阻滞的时间及恢复到大致正常心率的时间缩短。
Contrasted with the prevent group, the treat group and the model control group coming back of I Atrioventricular block or normal electrocardiography gets earlier.
预防组、治疗组与模型组比较,恢复到一度房室传导阻滞的时间及恢复到大致正常心率的时间缩短。
Contrasted with the prevent group, the treat group and the model control group coming back of I Atrioventricular block or normal electrocardiography gets earlier.
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