目的:证实抗P糖蛋白单克隆抗体(JSB1 )能逆转人肾癌的天然多药耐药(MDR)性。
Purpose:To illustrate anti P gp monoclonal antibody(JSB 1) can reverse multidrug resistance(MDR) of the human kidney cancer.
例如,委员会使用的关于单克隆抗体西妥昔单抗和帕尼单抗(它们抑制转移性结直肠癌的表皮生长因子受体egfr)的数据。
For example, the Panel used data for the monoclonal antibodies cetuximab and panitumumab, which inhibit the EGF receptor (EGFR) in metastatic colorectal cancer.
用单克隆抗体55,79检查了普通型急性淋巴细胞性白血病抗原(CALLA)的组织分布特点。
The tissue distribution of common acute lymphoblastic leukaemia antigen (CALLA) was detected by monoclonal antibodies 55, 79.
目的:建立一条从孕早期妇女血清中分离纯化早孕因子(EPF)的技术路线,获得高纯度的EPF,并对制备抗epf单克隆抗体进行阶段性的初步尝试。
Object: Set up a method of isolation and purification of early pregnancy factor (EPF) from human pregnancy sera and get pure EPF, then attempt to prepare monoclonal antibodies.
目的:鉴定抑制肺癌细胞生长的功能性单克隆抗体1E2及其抗原,为治疗肺癌提供有潜力的靶向抗体治疗剂和分子靶位。
Objective: To identify a functional monoclonal antibody 1E2 against lung cancer and its antigen, so as to provide a candidate antibody drug and molecule target for the anti-lung cancer therapy.
目的建立治疗性单克隆抗体溶液持续器官灌注模型,应用抗大鼠树突状细胞单克隆抗体(WZD)降低大鼠移植脾的免疫原性。
Objective To reduce immunogenicity of the donor spleen, a rat model of continuous perfusion of graft was established with therapeutic anti dendritic cells monoclonal antibody (WZD).
目的耐热性肠毒素ST1单克隆抗体制备及在感染性腹泻诊断中的应用。
Objective To prepare monoclonal antibody(McAb) against heat-stable enterotoxin(ST1) and study its clinical application in infectious diarrhea.
同时,利用此重组蛋白为抗原,制备了小鼠组织因子的小鼠源功能阻断性单克隆抗体,在血浆凝集实验中证明其对小鼠组织因子的活性有明显抑制作用。
Using this recombinant mTF as immunogen, a murine monoclonal function-blocking antibody to mTF was also generated, which can inhibit mTF-initiated plasma clotting in vitro.
目的对天然抗角蛋白单克隆抗体3B4的多反应性进行鉴定,并探讨其分子基础。
Objective To identify the polyreactivity of a monoclonal natural anti-keratin autoantibody 3B4 and to analyze its possible molecular mechanism.
本文用elisa间接法,研究并建立了抗鸡传染性法氏囊病毒单克隆抗体的检测体系。
By use of ELISA test, a detective and remedy system by using McAb of IBDV has been set up and studied.
这项合作将继续成功地查明了许多高品质的治疗性单克隆抗体导致候选人。
The collaboration continues to be successful in identifying numerous high quality therapeutic monoclonal antibody lead candidates.
采用杂交瘤技术制备人源性单克隆抗体存在许多困难,90年代初期出现了抗体库技术,为抗体的制备提供了新的途径。
But it is difficult to make humanized monoclonal antibody with hybridoma technique. Antibody library technique coming forth in the early 90s provides the new method to get the antibody.
然而,它是首次显示了针对糖脂发挥作用的单克隆抗体的有效性。
Moreover, it is the first to show effectiveness of a monoclonal antibody targeting a glycolipid.
研究用放射性核素标记单克隆抗体作为肿瘤的导向药物,是核药物化学领域的研究热点。
The monoclonal antibody(MoAb) technique has been regarded as an encouraging and promising approach which may lead to exciting advances in both diagnosis and therapy of human cancer.
兔单克隆抗体识别内源性的PCK2总蛋白水平。
PCK2 (D3E11) Rabbit mAb recognizes endogenous levels of total PCK2 protein.
兔单克隆抗体识别内源性的胰岛素总蛋白水平。
Insulin (C27C9) Rabbit mAb detects endogenous levels of total insulin protein.
摘 要?目的:研制抗肝癌干细胞的功能性单克隆抗体,为肝癌干细胞的靶向治疗提供候选抗体药物。
Objective:To prepare functional monoclonal antibodies(McAbs) against liver cancer stem cells, so as to provide candidate antibody drugs for stem cell-targeted therapy of liver cancer.
兔单克隆抗体识别内源性的延胡索酸酶总蛋白水平。
Fumarase (D9C5) Rabbit mAb recognizes endogenous levels of total fumarase protein.
兔单克隆抗体识别内源性的IRS - 1总蛋白水平。此抗体与IRS - 2蛋白没有交叉反应。
IRS-1 (59g8) Rabbit mAb detects endogenous levels of total IRS-1 protein. The antibody does not cross-react with IRS-2.
结论早期应用抗gbm抗体的中和性单克隆抗体能够有效改善抗gbm肾炎大鼠的肾脏病变。
Conclusion the early application of neutralizing monoclonal antibodies to anti-GBM antibodies can effectively improve the kidney lesions of anti-GBM nephritis rats.
以免疫组化法用纯化蛋白制备的单克隆抗体分析NBEAL1表达与胶质瘤病理分级的相关性。
A NBEAL1 protein specific monoclonal antibody was prepared and was used to study the relationship of NBEAL1 expression with pathological grades of glioma.
单克隆抗体因具有高度均质性和特异性的特点,在生物医学领域得到广泛的应用。
Monoclonal antibody has high sensitivity and specificity, so it is widely used in biomedicine.
兔单克隆抗体识别内源性的乙酰辅酶A羧化酶2总蛋白水平。
Acetyl-CoA carboxylase 2 (D5B9) Rabbit mAb recognizes endogenous levels of total acetyl-CoA carboxylase 2 protein.
兔单克隆抗体识别内源性的全部己糖激酶i蛋白水平。
Hexokinase I (C35C4) Rabbit mAb detects endogenous levels of total hexokinase I protein.
采用单克隆抗体和阳性血清经elisa、阻断elisa、免疫印迹分析重组蛋白的免疫反应性。
Its immunoreactivity was analyzed by Western blot, ELISA and blocking ELISA using MAb and positive serum.
采用单克隆抗体和阳性血清经elisa、阻断elisa、免疫印迹分析重组蛋白的免疫反应性。
Its immunoreactivity was analyzed by Western blot, ELISA and blocking ELISA using MAb and positive serum.
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