目的研究压力超负荷时心肌闰盘的变化。
Objective To investigate the change of intercalated discs induced by pressure overload.
结果：正常小鼠心肌中未见穿孔素阳性表达，连接蛋白43在心肌闰盘中呈阳性表达。
Results in normal mice, perforin was negative and connexin 43 was located in the intercalated disks of cardiac muscle.
结果术后10周手术组心肌闰盘的粘着膜、桥粒、间隙连接结构模糊，连接间隙增宽；
Results At the 10th week after constriction, the structure of cadherin, desmosome and gap junction in intercalated discs were destroyed, gap of intercellular space widened.
结果连接蛋白43和结蛋白在正常小鼠心肌闰盘中定位分布，均匀存在，后者还在肌节横纹中显示阳性；
Results In normal mice, connexin 43 and desmin are located in the intercalated disks of cardiac muscle, and the latter also revealed a positive immunoreactivity in the cross striations of sarcomeres.
可以看到细胞核和平等排列的心肌纤维，心肌纤维间的线形粉红色条纹为闰盘。
Note the central nuclei and the syncytial arrangement of the fibers, some of which have pale pink intercalated disks.
本实验对大鼠心房心肌细胞的肌浆网与闰盘间的关系进行了超微结构观察。
The ultrastructure of the relationship between the sarcoplasmic (SR) and the intercalated disk in the atrial myocardial cells of the heart is studied.
结果：（1）胎鼠心肌细胞Cx43呈斑点状遍布于心肌细胞侧—侧连接、细胞质内和闰盘处。
Results:(1) The Cx43 immunolabelling of fetus rat myocardium had a punctate distribution in cytoplasm and over the entire surface of the myocardium, and few located at intercalated disk .
结论：骨髓间质干细胞分化为心肌细胞过程中，随培养时间延长及细胞密度增加逐渐形成闰盘样结构。
CONCLUSION: During the process of BMMSCs differentiating into cardiomyocytes, intercalated disc-like structure is gradually formed with increase in culture time and cell density.
结论：骨髓间质干细胞分化为心肌细胞过程中，随培养时间延长及细胞密度增加逐渐形成闰盘样结构。
CONCLUSION: During the process of BMMSCs differentiating into cardiomyocytes, intercalated disc-like structure is gradually formed with increase in culture time and cell density.
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