目的优化阿昔洛韦白蛋白微球的制备工艺，并对其形态学性质、载药量、体外释药进行考察。
OBJECTIVE To study the preparation of aciclovir loaded albumin microspheres (ACV BSA MS) and evaluate its morphology, drug loading and release in vitro.
研究发现改进的乳化交联法能获得载药量较高的明胶微球。
The drug load in microspheres was enhanced by a modified emulsion crosslink method.
初步分析表明，因聚合物中残留的微小杂质的影响，造成了所制备的载药微球过低的载药量及包封率。
The results indicated that the microspheres had poor drug loading and entrapment efficiency abilities due to residual impurities contained in polymer.
结果：经过六个月的试验，汉防己甲素微球的外观性状、载药量、渗漏率、微生物稳定性无明显改变；但在六个月的加速试验中，包封率则下降，渗漏率增加。
Results:Through the test of six months, properties of appearance, amount of medicine loaded, seal rate, seepage rate, microbial stability have not obviously change.
目的考察聚乳酸相对分子量对利福平聚乳酸微球形态、载药量及微球中药物分布状态的影响。
Aim To discover the effect of molecular weight of polylactic acid on the shape, drug content and drug distribution state of rifampicin polylactic acid microspheres.
该方法制备的左氧氟沙星-壳聚糖缓释微球载药量为43.88%，体外累积释放度的线形关系良好。
The drug-loading rate of this chitosan-levofloxacin sustained-release microsphere is 43.88%. Its in vitro dissolubility is good.
研究发现，只有加入适量乙醇作为药物颗粒预处理剂才能制得形态圆整、粒径均一且具有较高载药量的微球。
Results showed that only when the CH331 particles were pretreated with a suitable amount of ethanol could lead to more uniform sizes, better appearance and higher drug loading for the microspheres.
吸水度高的微球载药量和包封率较吸水度低的微球高。
Compared to microspheres with low water absorbing rate, the high batches had higher drug-loading rate and entrapment rate.
吸水度高的微球载药量和包封率较吸水度低的微球高。
Compared to microspheres with low water absorbing rate, the high batches had higher drug-loading rate and entrapment rate.
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