超声微泡造影剂在疾病诊断与治疗中的作用日渐明显。
The effects of ultrasound contrast agent in diagnosis and treatment of diseases have made gradual improvement.
本文对超声微泡造影剂在肿瘤基因治疗中的应用及进展进行综述。
The application and process of ultrasound microbubbles in gene therapy of tumor were reviewed in this article.
目的探讨用超声微泡造影剂促进VEGF基因治疗兔下肢缺血的可行性。
Objective to investigate the feasibility of microbubble-mediated VEGF gene delivery to treat rabbit's hind limb ischemia resulted from acute artery occlusion.
第一部分检测了微泡造影剂和超声对体外培养的RB细胞生长活性的影响。
The first part was about the influence of microbubble and ultrasound used to RB cells.
另在体外制作人工血栓模型，在二维超声下观察微泡造影剂对声学信号的影响。
The effects of the targeted microbubbles on the ultrasonic signal was observed in an artificial thrombus model.
本发明属于生物医学工程领域，更具体地说，本发明涉及一种新型靶向微泡造影剂。
The invention belongs to the biomedical engineering field, in particular relating to a novel targeted microbubble contrast agent.
同时采用超声辐射力法以增加靶向性微泡造影剂在血管壁上的黏附效率，改善成像的性能。
Meanwhile, the ultrasonic radiation force method is used to get the higher adhering efficiency for the targeted micro-bubble contrast agent, which will improve the imaging quality.
研究表明，超声微泡造影剂作为药物和基因的载体将有可能为肿瘤的治疗提供一条新的途径。
Present researches showed that the application of ultrasound contrast agent in delivery of drugs and gene may open up a new pathway for tumor treatment.
采用超声微泡造影剂介导的VEGF基因转染，能明显增强大鼠心肌组织VEGF蛋白的表达。
VEGF protein expression was higher in ischemic myocardium of rats received ultrasound-mediated microbubble destruction for gene delivery than in ischemic myocardium of rats in controls.
动物肝脏造影实验证明经过多层聚电解质膜包覆的微泡造影剂能够有效增强兔肝实质显像效果。
In vivo experiment showed that polyelectrolyte multilayer film-coated UCA effectively enhanced the imaging of rabbit's liver parenchyma.
按膜材料的不同，包膜微泡造影剂可分为白蛋白类、非离子表面活性剂类、脂质体类和多聚体类。
According to different membrane materials, Encapsulated microbubbles ultrasound contrast agent can be divided into several categories such as albumin, liposome, polymer.
结论靶向超声纳米对比剂具有特异性和敏感性，纳米级微泡造影剂用于超声造影增强是完全可行的。
Conclusion Targeted nano ultrasound contrast agents are specific and sensitive, nanoscale for ultrasound microbubble contrast enhancement is completely feasible.
目前的研究表明，超声微泡造影剂在治疗中也显示出巨大潜力，可作为一种有效的基因或药物运载工具。
Present study shows that ultrasound contrast agent which may be effective carrier of drug and gene have great potential in treatment.
随着新型超声微泡造影剂的研究和应用，超声微泡不仅能增强超声造影，而且也能作为运送基因或药物的载体。
With the research and application of the new ultrasound microbubble contrast agents, ultrasonic microbubbles can not only help to image, but they can also be used as genes or drug carriers.
目的用PLLA - PEG - plla共聚物为外壳材料制备微泡造影剂，建立体外声学性质测定装置和方法。
Objective To prepare an ultrasound microbubble contrast agent using PLLA-PEG-PLLA copolymer as the shell material, and test their acoustic characteristics in vitro.
本文对近年来有关超声微泡造影剂作为基因转染载体的作用机制、影响因素、转染实验和应用等方面的研究作了总结。
This context concludes many researches about ultrasound microbubble: a novel gene vector in recent years. These researches include functional mechanism, influence factor, transfect...
近几年，国内外学者利用超声联合微泡造影技术所产生的生物学效应，实现了微泡造影剂携载药物和基因对肿瘤的靶向治疗。
Resently years, researchers utilize biological effects generated by microbubble contrast agent combined ultrasound techniques to implement therapy of tumor by microbubble carrying drug and gene.
MFI可能会改进这一状况。采用造影剂闪烁-再灌注技术，高能闪烁脉冲破坏对比剂微泡而低能脉冲显示出再灌注。
MFI may be of help in this setting. With this flash-replenishment technique, high-power flash pulses destroy the contrast microbubbles while low-power pulses demonstrate replenishment, Halpern said.
目的探索应用人工合成高分子聚合材料制备微泡超声造影剂的方法并观察其体外显影效果。
Objective to explore a way to produce a novel high molecular polymer ultrasound contrast agents, and to explore its effect of enhancing ultrasound imaging in vitro experiment.
该造影剂包括传统的微泡和固态金属纳米颗粒或它们的组合。
The contrast agent comprises conventional microbubbles as well as solid metal nano-particles or combinations thereof.
微泡可能成为靶向治疗的载体，超声造影剂作为一种新型、无创的运载系统具有广阔的应用前景。
Microbubble may be a vector for target treatment. Therefore, ultrasound contrast agent as an new and non-invasive vector for treatment holds considerable promises.
含气体微泡既可以作为医学超声显像的造影剂，又可以作为药物或基因载体。
As ultrasound contrast agents for medical ultrasound imaging, gas-filled microbubbles can also be used as drugs or gene carriers.
目的探讨脂质微泡与高分子聚合物超声造影剂在大鼠肠系膜微循环中的流变学特征。
Objective To investigate the microvascular rheology characteristics of lipid - and polymer-shelled ultrasound contrast agents in mesentery microcirculation of rats.
目的探讨自制氟烷微泡超声造影剂对兔肾的显影作用。
Objective To investigate the effect of a self-made albumin perfluorocarbon ultrasound contrast agent in enhancing the imaging of normal rabbit kidney.
方法以静电吸附法将抗VEGF抗体连接到脂质体造影剂微泡的表面；
Methods The anti-VEGF antibody was connected to the surface of liposome ultrasound contrast microbubbles by the electrostatic attraction way and its physical characteristics were detected.
采用造影剂闪烁-再灌注技术，高能闪烁脉冲破坏对比剂微泡而低能脉冲显示出再灌注。
With this flash-replenishment technique, high-power flash pulses destroy the contrast microbubbles while low-power pulses demonstrate replenishment, Halpern said.
本文对有关微泡超声造影剂作为药物载体的作用原理、制备要求、制备方法、特点和应用等方面的研究作了介绍。
This context reviewed the principles, the preparation, characteristic and application of the microbubbles as a vector of the drug delivery.
摘要：目的制备多层聚电解质膜包覆的微泡超声造影剂，观察其对正常兔肝脏超声显影效果。
ABSTRACT: Objective To prepare polyelectrolyte multilayer film-coated microbubble ultrasound contrast agent (UCA) and evaluate its effects in contrast imaging on normal rabbit's liver parenchyma.
结果 注射后两种造影剂在大鼠肠系膜微循环内均可随血流移动，仅见少量脂质微泡短暂滞留。
Results The contrast agents could move with the blood flow in the microcirculation. Only transient retention of few lipid microbubbles was observed in the venules.
结果声空化法能够制备出粒径分布均匀的超声造影剂微泡，聚电解质有效地组装到ST68 - PF C微泡表面。
Results the obtained microbubble UCA exhibited a narrow size distribution. The polyelectrolytes were successfully assembled onto the surface of ST68-PFC microbubbles.
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