而我们的退步，你也应该有着很大责任。
And our a step backwards, you should also have a very great responsibility.
同时，美国50家州级的保险监管机构都负有很大责任。
Meanwhile America's 50 state-level insurance regulators have much to answer for.
事实是黑格在两党合作谈判中承担很大责任。
In fact, he is very much taken with the coalition he helped to broker.
多数经济史学家们现在得出结论，该法对当时的全球大萧条负有很大责任。
Most economic historians now conclude that the tariff contributed importantly to the severity of the world-wide Great Depression.
规范委员会有很大责任，因为他们仅提供带注释的实例，这暗示注释是JPA的首选机制。
The specification committees are especially guilty, since they only provide annotated examples, implying that annotation is the preferred mechanism for JPA.
毫无疑问，北半球的工业化对温室气体量的增多负有很大责任。发达国家应该立即采取措施。
To be sure, industrialization in the North contributed enormously to increased greenhouse gas concentrations. Developed countries must take significant steps immediately.
首相戈登·布朗要为第三个不平衡负很大责任，这可能要留给他的继任者来纠正了，因为选民们似乎决意把他踢出局。
The third, for which Gordon Brown is largely responsible, will probably fall to his successor to correct, since the electorate seems minded to turf him out.
技术层面也有影响，银行的放空也要为拖垮CMBX指数付出很大责任，他们贷款并利用衍伸性商品对冲风险。
Technical factors are also at work: banks are dragging down the CMBX further by shorting it, using credit derivatives, to hedge risks in their loan books.
但我在公司里的职位是要负起很大责任，要管理超过330名的员工。在我之下，我已经建立起一个有能力经营公司的团队。
While I have a very responsible position in my company and manage over 330 employees, I have built a management team underneath me that is able to run the business.
他们的工作量很大，我们也赋予了他们很多责任。
They have a heavy workload and we give them a lot of responsibilities.
“这里有很多机会，也有很大的压力和责任驱使我们思考如何城市化。”濑户说。
"There is an enormous opportunity here, and a lot of pressure and responsibility to think about how we urbanize," says Seto.
我想对于很多人来说，很大的可能就是你觉得它不是你的责任，或者它只是一个麻烦。
I think that for many, there's a part of you that feels it's not your responsibility, or that it's a hassle.
所以，它们不需要透露任何关于财政或管理，且很大程度上不对公众负责任。
Thus they need not reveal anything about their finances or their governance, and are largely unaccountable to the public.
一旦有新宠物融入家庭，这些孩子很快就会懂得饲养宠物要负起很大的责任。
When a new pet arrives at home, very soon the kids will learn that there is a huge responsibility in pet ownership.
这是一个示意图,"你对此毫无责任",是视皮质的示意图,我们会发现,这里做了很大程度的简化
This is a sort of schematic diagram "You're not responsible for this" of parts of the visual cortex, and the thing to realize about this is it's extraordinarily simplified.
另外还有一个阻碍因素，尤其对制药公司而言：“怀孕女性不是一个很大的市场，而且还需对这种潜在风险承担责任。”Baylis说。
There are other disincentives, too, especially for pharmaceutical companies: Pregnant women are "not a huge market, and it does carry this potential risk of liability," Baylis says.
这是个很大的责任，但这并不会给我带来消极的影响，而只会成为推动我前进的源泉。
It is a great responsibility, but that's not something that is negative for me - it's only a source of motivation.
我认为这是一个很大的责任。我很骄傲他们信任我并让我加入。
I considered it a great responsibility, and I am very proud of the trust they put in me.
她知道她很幸运，同时也意识到有很大的责任。
She knew that with that luck and fortune also comes great responsibility.
如果你已准备好要调整你的实务工作，承担起这项责任，你会有很大的可能性可以改善工作成效，并且影响整个工作团队。
If you're prepared to change your practices and take on the responsibility, there are great opportunities to improve your effectiveness and your impact on the teams you support.
这件小事中体现的意义很大：她表现出了充分的自信可以担起责任，因为她知道她周围的人会支持她。
It's a small thing that was big: she showed she had the confidence to be in charge because she knew she was surrounded by people who would support her.
现在，它意味着很大的责任心。
科学家们验证了先前的猜测，紫外线和日光对催化画布上的铬黄的化学反应要负很大的责任。
The scientists validated previous hunches that UV light and sunlight are to blame for catalyzing chemical reactions of chrome yellow on canvas.
现如今，这种责任感在很大程度上取决于进行高频率操作的交易员，这一团体的交易量约计占整个股市交易量的三分之二。
Today that responsibility falls largely on a group of high-frequency traders who make up an estimated two-thirds of stock-market volume.
我询问另外一位法国调查与分析局的调查人员，奥利维•费兰特，出具一份不指明错误和责任的调查报告的难度是否很大。
When I asked another B.E.A. investigator, Olivier Ferrante, whether it is difficult to write the reports without pointing out mistakes, he acknowledged that it is a matter of craft.
我询问另外一位法国调查与分析局的调查人员，奥利维•费兰特，出具一份不指明错误和责任的调查报告的难度是否很大。
When I asked another B.E.A. investigator, Olivier Ferrante, whether it is difficult to write the reports without pointing out mistakes, he acknowledged that it is a matter of craft.
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