OR c结合DNA后允许其它蛋白如cdc6和MCMs的有序结合，从而形成前复制复合体(Pre - RCs)。
ORC binding to DNA permits the ordered binding of other proteins such as cdc6 and MCMs to form pre-replication complexes (Pre-RCs).
前复制复合体（Pre-RC）在有丝分裂末期/G1早期随着CDT1和cdc6的结合而形成，允许异源六聚化的MCM2-7复合体的结合。
The prereplication complex (Pre-RC) forms in late mitosis/early G1 phase beginning with the binding of CDT1 and cdc6 to the origin, which allows binding of the heterohexameric MCM2-7 complex.
前复制复合体（Pre-RC）在有丝分裂末期/G1早期随着CDT1和cdc6的结合而形成，允许异源六聚化的MCM2-7复合体的结合。
The pre-replication complex (Pre-RC) forms in late mitosis/early G1 phase beginning with the binding of CDT1 and cdc6 to the origin, which allows binding of the heterohexameric MCM2-7 complex.
通过cdk2磷酸化的cdc6阻止其降解，允许前复制复合体的形成（5）。
Phosphorylation of cdc6 by cdk2 prevents its degradation, allowing pre-replication complexes to form (5).
通过cdk2磷酸化的cdc6阻止其降解，允许前复制复合体的形成（5）。
Phosphorylation of cdc6 by cdk2 prevents its degradation, allowing pre-replication complexes to form (5).
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