四个生产异维甲酸的厂家分别有罗氏公司、迈兰实验室、巴尔制药和兰巴克斯实验室公司。
The four manufacturers of isotretinoin are Roche Holding, Mylan Laboratories, Barr Pharmaceuticals and Ranbaxy Laboratories.
关于这些药物存在很多的争论，这导致了很多皮肤科医生开异维甲酸(青春痘特效药)的处方时非常小心。
There has been a lot of controversy regarding these drugs and that has made many dermatologists cautious about prescribing isotretinoin (Accutane).
星期一是文迪雅，星期二是Tysabri，昨天是粉刺药异维甲酸，今天，我们会错过什么么？
There was Avandia on Monday, Tysabri Tuesday, and acne treatment Accutane yesterday. Are we missing something today?
我们也知道，一种广泛使用的治疗青春痘的药物阿克唐丸(异维甲酸)一直与抑郁加重有关，虽然相关原因还未确定。
We also know that a widely used drug that treats acne, Accutane (isotretinoin), has been associated with an increase in depression, although no causal link has been established.
例如，青春痘特效药及其通用版本(即异维甲酸)是用来清除严重性粉刺的，但对于一些人来说，抑郁和自杀倾向就是潜在的威胁。
For example, Accutane and its generic version (isotretinoin) are prescribed to clear up severe acne, but depression and suicidal thoughts are a potential risk for some people.
由于具有潜在的毒性如引发胎儿畸形，因此女性在怀孕、哺乳期间禁止使用，在服用维甲酸、异维甲酸期间也不可以怀孕。
Due to potential birth defects, a woman must not take this medication while pregnant or breast feeding and must not become pregnant while taking isotretinoin.
抑郁症是一种复杂的病症，因此很难把它的发生归结于单一的因素。比如异维甲酸使用者常常患有严重的痤疮，这种病本身就可能导致抑郁症。
Depression is a complex disorder and, therefore, difficult to pin down to a single cause. For example, Accutane users often have severe acne, which itself may lead to depression.
这个项目并没有收到很好的成效-从2006年五月到今年6月份，102，606个至少接受过一次异维甲酸治疗的病人其中有178个妇女在怀孕初期使用。DowJones报道。
The program hasn't worked perfectly — 178 women out of 102,606 who received at least one isotretinoin prescription became pregnant from March 1, 2006, through June of this year, Dow Jones reports.
结论：合成的近红外标记的维甲酸造影剂可以用于检测人类骨肿瘤的异种移植，实现个体化分子诊疗的同时减少全身毒性。
Conclusion: Synthetic NIR-labeled retinoid agents can be used to detect human cancer xenografts as the agent is internalized by cancer cells, and it can reduce systemic toxicity.
结论：合成的近红外标记的维甲酸造影剂可以用于检测人类骨肿瘤的异种移植，实现个体化分子诊疗的同时减少全身毒性。
Conclusion: Synthetic NIR-labeled retinoid agents can be used to detect human cancer xenografts as the agent is internalized by cancer cells, and it can reduce systemic toxicity.
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