目的建立一个简便的研究延迟性排斥反应的猪—猴异种心脏移植模型。
Objective to establish a simple pig-to-monkey xenograft model to study delayed xenograft rejection (DXR).
目的:探讨血红素氧合酶- 1在延迟性异种心脏移植排斥反应中的表达及意义。
Objective: To investigate the expression and significance of heme oxygenase-1 (HO-1) in delayed cardiac xenograft rejection in NIH-Wistar.
在豚鼠—大鼠异种心脏移植中,给以眼镜蛇毒因子以避免发生超急性排斥反应,制作延迟性排斥反应模型。
In guinea pig to rat heart xenotransplantation model, cobra venom factor is administrated to avoid hyperacute rejection, and thus delayed xenograft rejection model is made.
目的探讨眼睛蛇毒因子(CVF)对血清总补体活性及对豚鼠到大鼠异种心脏移植超急性排斥反应的影响。
Objective To investigate the effect of purified cobra venom factor (CVF) in rats and the efficacy in preventing hyperacute rejection (HAR) after discordant xenotransplantation.
多年来心脏移植学家们不断地进行异种心脏移植的基础研究,至今异种心脏移植排斥问题尚无良好的解决办法。
Cardiacians have been working on cardiac xenotransplantation for many years, buthyperacute rejection in discordant cardiac xenotransplantation has never been solved.
目的建立国外常用的啮齿类动物颈部异位心脏移植标准术式,并介绍其在金黄仓鼠大鼠异种移植中的应用。
Objectives To establish standard cervical heart transplantation in rodents that was widely used abroad and introduce its application in golden hamster rat xenotransplantation.
结论:袖套法建立小鼠→大鼠颈部异位心脏移植模型操作简便、易于观察、稳定可靠,是研究异种移植较理想的动物模型。
To establish a model of mouse-to-rat cardiac heterotopic xenotransplantation in neck by modified cuff technique and observe the dynamic changes of pathologic features in xenografts.
结论:本诱导方案能明显延长异基因异位大鼠心脏移植物存活时间,是便于临床推广应用的一种有效方法,该移植耐受的形成涉及多种机制。
Conclusions: The tolerance induction protocol significantly prolonged cardiac allograft survival in rat, and it appears to be worthy of a clinical trial. This tolerance involved multiple mechanisms.
结论:本诱导方案能明显延长异基因异位大鼠心脏移植物存活时间,是便于临床推广应用的一种有效方法,该移植耐受的形成涉及多种机制。
Conclusions: The tolerance induction protocol significantly prolonged cardiac allograft survival in rat, and it appears to be worthy of a clinical trial. This tolerance involved multiple mechanisms.
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