目的探讨分化型甲状腺癌（DTC）放射性碘治疗过程中应用维甲酸（RA）治疗的作用。
Objective Assess the changes of iodine metabolism reinduced by RA in differentiated thyroid carcinoma(DTC).
分化诱导剂被广泛应用于肿瘤的研究，在肿瘤的预防和治疗方面取得一定的进展，其中以维甲酸类药物效果肯定。
Agents that induce cell differentiation have been widely used in tumor research and achieved progress in the prevention and treatment of tumor. among them, retinoid drug shows confirmative effect.
维甲酸类药物目前在银屑病治疗中广泛应用，疗效较为满意但机制未明。
Retinoids has been used widely in the therapy of psoriasis, which achieved satisfactory effect with unclear mechanism.
方法：应用全反式维甲酸诱导前列腺癌DU 145细胞凋亡，建立细胞凋亡模型，采用基于PCR的改良消减杂交技术克隆与凋亡相关的基因。
Methods Improved PCR-based subtractive hybridization was used to clone the genes from apoptotic prostatic carcinoma cell line DU-145 cells induced by ATRA.
方法：应用全反式维甲酸诱导前列腺癌DU 145细胞凋亡，建立细胞凋亡模型，采用基于PCR的改良消减杂交技术克隆与凋亡相关的基因。
Methods Improved PCR-based subtractive hybridization was used to clone the genes from apoptotic prostatic carcinoma cell line DU-145 cells induced by ATRA.
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