胞嘧啶甲基化是否能够解释这种差异还有待考察,但是的确是有些什么东西存在着。
Whether cytosine methylation is the explanation for this difference has yet to be tested, but something is clearly happening.
未来可以深入研究某种甲基化差异和具体疾病的关系,然后针对那些区域用药治疗。
Future research could peg where certain methylation differences are associated with specific diseases, then target those areas with drugs or other treatments.
英国的40名患者参加了一项持续研究,在这项研究中,他们人生中的很多方面都被记录下来,研究者们观察了他们基因甲基化的差异。
In 40 research patients in the UK that are participating in an ongoing study that has documented many aspects of their lives, researchers looked at differences in gene methylation.
他们选择的对象既有生活水平非常高的也有非常低的,并且,他们覆盖了其中的20000个基因来观察dna甲基化的差异。
They chose subjects that had come from either very high or very low standards of living, and they looked at differences in DNA methylation across some 20, 000 genes.
斯兹夫博士表示,这一差别意味着自杀组的基因过甲基化并非整体差异,而像是对一些特定情况的反应,比如说童年所遭受的虐待。
This suggests that the hypermethylation in the suicide group was not just a general difference, says Dr Szyf, but rather a response to something specific, such as abuse suffered in childhood.
作为对比,大脑的另一部分、与情绪无关的小脑,它里面基因的甲基化水平在两组中并无差异。
In another part of the brain, the cerebellum, however, which is not involved in mood, there were no differences in the levels of methylation between the two groups.
研究发现,母亲孕期吸烟,孩子在DNA甲基化上表现出差异,DNA甲基化是一种表观遗传学机制,在这个过程中化学小分子添加到DNA上。
The study found that children exposed in the womb to maternal smoking had differences in DNA methylation, an epigenetic mechanism in which small chemical compounds are added to DNA.
目的:筛选胃癌和癌旁正常胃组织间DNA甲基化差异片段并进行相关生物信息学分析。
Objective To isolate the differentially methylated DNA sequences betweengastric cancer and adjacent normal gastric mucosa and analyze them with relative bioinformatics methods.
目的筛选和分析胃癌和正常胃组织间DNA甲基化差异片段。
Objective: To isolate and analyze the differentially methylated DNA sequences between gastric cancer and normal gastric mucosa.
三个候选甲基化差异通过靶向焦磷酸测序实验进行了验证。
Three candidate methylation differences were validated by targeted pyrosequencing assays.
亚硫酸氢钠测序检测表达有差异的基因调节序列的甲基化状态。
Bisulfite sequencing was used to determine the methylation status of the regulatory sequence in which gene the expression are significantly difference.
目的:通过比较不同细胞类型胰岛组织特异性基因dna甲基化程度差异及与基因表达的关系,探讨DNA甲基化在胰岛组织特异性基因表达和胰岛分化中的作用。
Objective: the investigate on the role of DNA methylation in the islet-tissue specific genes expression and the differentiation of islet cells.
活化的差异组蛋白修饰标记物对抑制基因的改变伴随着这些DNA甲基化改变。
Differential histone modification marks of active versus repressed genes accompany these DNA methylation changes.
活化的差异组蛋白修饰标记物对抑制基因的改变伴随着这些DNA甲基化改变。
Differential histone modification marks of active versus repressed genes accompany these DNA methylation changes.
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