主要付反应是局部刺激性较大。
方法：按《新药审批办法》有关外用药局部刺激性研究的规定进行。
Methods: the methods in the "Approval Provision of New Drug" were used.
本实验显示新型根管充填剂复方牡蛎粉无细胞毒性、无基因毒性、无皮肤致敏性以及局部刺激性，具有良好的生物相容性。
The new root canal filling material showed no detected cytotoxic, genotoxic effect, potential of skin sensitization and topical irritation and has good biocompatibility.
对于肌肉注射刺激性大的药物可通过稀释药液局部皮肤处理等缓解疼痛。
For high irritable drugs, one should dilute it and handle local skin properly.
结论该氟片使用方便，局部未见刺激性，可能是临床提高唾液氟浓度、预防龋齿的有效方法，但还需进一步研究。
Conclusion The tablet appears to be a clinically useful means of raising the F- concentration of saliva in the mouth, but further research is needed.
结论该氟片使用方便，局部未见刺激性，可能是临床提高唾液氟浓度、预防龋齿的有效方法，但还需进一步研究。
Conclusion The tablet appears to be a clinically useful means of raising the F- concentration of saliva in the mouth, but further research is needed.
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