研究者们利用小鼠晶胚来培育脑组织,并且设定了一种环境,在此环境下,脑组织会逐渐流失左旋多巴胺神经细胞,这与帕金逊症的症状非常相似。
Using tissue from mouse embryos, researchers prepared brain cultures using conditions that favor the slowly progressing loss of dopamine neurons, a hallmark of the disease.
与她的同事发现,实验用小鼠住在一起的时候,鼠脑中缝背核里的多巴胺神经元比较不活跃。
Tye and her colleagues found that when mice were housed together, dopamine neurons in the DRN were relatively inactive.
在小鼠中,肌酸可阻止多巴胺能神经元的缺失。
In mice, creatine was shown to prevent the loss of dopamine-producing brain cells.
结果:EDGE能促进正常小鼠胃排空,对阿托品、多巴胺引起的胃排空减慢有明显促进作用,对肾上腺素引起的胃排空抑制影响不大。
Results: EDGE significantly promoted gastric emptying in both normal mice and slow gastric emptying models induced by atropine and dopamine, had no effect on adrenaline-induced slow gastric emptying.
结论移植的神经干细胞能在PD模型小鼠纹状体存活,并可分化出特定的多巴胺能神经元。
ConclusionsThe transplanted multipotent NSCs could survive, differentiate into functional dopamine neurons in the brains of PD model mice.
结论移植的神经干细胞能在PD模型小鼠纹状体存活,并可分化出特定的多巴胺能神经元。
ConclusionsThe transplanted multipotent NSCs could survive, differentiate into functional dopamine neurons in the brains of PD model mice.
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