目的：对炭疽毒素保护性抗原（PA）的不同结构域进行了缺失突变，以期找到免疫原性降低而功能变化不大的PA蛋白突变体。
Objective:To find protective antigen(PA) defective mutants of anthrax toxin with the same function as PA but with low immunogenicity, different domains of PA were mutated.
为了阐明BRD-7基因的作用机制，我们首先对其溴区结构域进行了初步的研究。
In order to clarify the function mechanism of this gene, we investigate an important motif of BRD 7, the bromodomain.
为此我们对蛋白质序列进行了结构域的划分和映射，并采用机器学习的方法提取出结构域之间的相互作用。
We then used a machine learning approach to deduce a protein interaction map that is most consistent with the underlying domain information.
然后用生物信息学方法对其结构域和功能作用位点进行分析和预测，并绘制该蛋白的进化树。
The structure and functions of the protein were analyzed by bioinformatics method, and the phylogenetic tree of the protein was drawn.
第一章共分为四节：第一节介绍了PKB的结构特征，对其三大结构域：PH结构域、激酶结构域、调节结构域，进行了详细描述。
The first chapter is divided into four sections. The first section gave a detailed description of the structure of PKB's three major domains: PH domain, kinase domain and regulate domain.
他们发现，由一个分子对另外一个EGFR激酶结构域的不对称激活类似于涉及调控细胞生长的细胞周期蛋白激活细胞周期蛋白依赖型激酶的方式。
They found that the asymmetric activation of one EGFR kinase domain by another is analogous to the activation of cyclin-dependent kinase (CDK) by cyclin, which are involved in regulating cell growth.
他们发现，由一个分子对另外一个EGFR激酶结构域的不对称激活类似于涉及调控细胞生长的细胞周期蛋白激活细胞周期蛋白依赖型激酶的方式。
They found that the asymmetric activation of one EGFR kinase domain by another is analogous to the activation of cyclin-dependent kinase (CDK) by cyclin, which are involved in regulating cell growth.
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