结论：EAAC 1反义寡核苷酸对急性脑缺血损伤有神经保护作用。
CONCLUSION: EAAC1 antisense oligonucleotide has the neuroprotective effect against acute cerebral ischemia injury.
目的观察vegf反义寡核苷酸对膀胱癌细胞VEGF表达的抑制情况。
Objective To study inhibition of VEGF expression in human bladder carcinoma cells by antisense oligonucleotides.
结果VEGF反义寡核苷酸对膀胱癌细胞的VEGF表达有明显的抑制作用。
Results VEGF antisense oligonucleotides obviously inhibited VEGF expression in human bladder carcinoma cells and proliferation of endothelial cells.
目的：利用纳米载体增强端粒酶反义寡核苷酸对肝脏肿瘤细胞生长的抑制作用。
Objective: To investigate the growth inhibition of antisense oligonucleotides of telomerase on liver tumor cell enhanced by albumin nanoparticles.
目的探讨IGF - IR反义寡核苷酸对食管癌ec9706细胞增殖、分化的影响。
Objective To investigate the effects of antisense oligodeoxynucleotides (ASODNs) of IGF-IR on the proliferation and differentiation of EC9706 cell line.
目的检测针对端粒酶rna的反义寡核苷酸对鼻咽癌hne - 1细胞株生长的影响。
Objective To investigate the effects of AS-ODN targeting against telomerase RNA on the growth of HNE-1 cell line.
结果：作用靶点不同的反义寡核苷酸对KB - A - 1细胞生长的抑制能力不同。
Results: the abilities of antisense oligonucleotides to inhibit the cell growth of KB-A-1 mainly depended upon their targeted sequences selected.
目的：探讨反义寡核苷酸对胆囊癌细胞端粒酶活性的影响及对胆囊癌细胞生长增殖的作用。
Objective: To study the antisense oligonucleotide mediated inhibition on telomerase activity and cell proliferation of GBC-SD cell.
采用DAPI染色技术观察hpk1反义寡核苷酸对OGD诱导的海马神经元凋亡的作用。
DAPI staining was used to investigate the role of HPK1 antisense oligodeoxynucleotides in hippocampus neuron death induced by OGD.
【摘要】目的探讨增殖细胞核抗原(pcna)反义寡核苷酸对大鼠胶质瘤生长的抑制作用。
Abstract Objective to study the inhibitory effect of PCNA antisense oligonucleotides on the growth of rat glioma.
目的观察增殖细胞核抗原（PCNA）基因反义脱氧寡核苷酸对人多形性胶质母细胞瘤细胞增殖的影响。
Objective To observe the effect of proliferating cells nuclear antigen (PCNA) antisense oligodeoxynucleotides on the proliferation of human multiform glioblastoma cells.
目的探讨IL12反义寡核苷酸对狼疮肾炎(LN)患者单个核细胞(PBMC)分泌免疫球蛋白的影响。
Objective To investigate the effect of IL 12 antisense oligonucleotides on immunoglobulin secretion by PBMC from patients with active lupus nephritis (LN).
目的：观察酰基辅酶a：胆固醇酰基转移酶1 (ACAT1)反义寡核苷酸对泡沫细胞(FC)形成的影响。
AIM: To study the effect of acyl coenzyme a: cholesteryl acyltransferase 1 (ACAT1) antisense oligonucleotides on the formation of foam cells (FC).
本研究目的旨在观察脂质体介导的VEGF - C反义寡核苷酸对肺癌裸鼠皮下种植瘤模型微淋巴管生成的影响。
The aim of this article is to investigate the effects on lymphangiogenesis of orthotopic implantation of lung cancer in nude mice with antisense oligonucleotides of VEGF-C.
目的研究角质形成细胞生长因子(KGF)及其受体(KGFR)反义寡核苷酸对KGF介导的细胞周期和凋亡变化的抑制作用。
Objective to investigate the effects of keratinocyte growth factor (KGF) and KGF receptor (KGFR) antisense oligonucleotide (ASODN) on cell cycle and apoptosis of HaCat cells.
与单独使用反义寡核苷酸相比较，萘二酰亚胺对寡核苷酸的共价修饰显著地提高了反义寡核苷酸对KB-A - 1细胞生长的抑制。
Compared with the unmodified one, the inhibition of antisense oligonucleotides to the growth of KB - a - 1 cell was increased by conjugating with naphthyl imide.
结论：在毛细管dna传感器构建中，溴化乙锭可作为荧光标记物对模式寡核苷酸进行检测。
CONCLUSION: In the construction of capillary DNA biosensors, EB can be taken as the fluorescent marker to detect the target oligonucleotide.
目的观察标记引物法、随机渗入标记法、末端转移标记法三种荧光标记法对寡核苷酸芯片杂交信号的影响。
Objective to observe the impact of three fluorescence marker methods of primer marker, random inleakage marker and terminal transfer marker to Oligonucleotide microarray hybridize signal.
目的探讨辐射促转染的胰岛素样生长因子1受体(IGF 1r)反义寡核苷酸(ason)对肿瘤组织的杀伤效果。
Objective to investigate the killing effect of insulin-like growth factor-1 receptor (IGF-1R) antisense oligodeoxynucleotides (ASON) in combination with ionizing radiation on tumor.
目的：探讨端粒酶逆转录酶(TERT)的反义寡核苷酸(A SODN)对甲状腺癌(TC)细胞凋亡的影响。
AIM: to investigate the effect of antisense oligonucleotides (ASODN) encoding telomerase reverse transcriptase (TERT) mRNA on thyroid carcinoma (TC) cell apoptosis.
方法设计一对寡核苷酸引物，其上游引物为突变引物。
Methods A pair of primer was designed and a mismatch nucleotide was introduced in its upstream primer.
应用三对具有特异性的寡核苷酸引物，进行多重pcr扩增。
Three pairs of oligonucleotide primer were used in triplex-PCR.
目的：观察eb病毒BHRF 1反义寡核苷酸片段对鼻咽癌SUNE1细胞株增殖的影响。
Objective: To investigate the effects of EBV BHRF1 antisense oligodeoxynucleotide (aso) on the proliferation of poorly differentiated nasopharyngeal carcinoma (SUNE1) cell lines.
紫外交联对大片段DNA固定率影响显著，但对氨基修饰的寡核苷酸影响不显著；
Ultraviolet crosslinking greatly affected the attachment rate of a large fragment of DNA, but did not noticeably affect the attachment rate of the amino-modified oligonucleotides.
根据肺炎支原体细胞粘附素蛋白质的基因保守区两侧序列，设计并合成一对变性寡核苷酸引物L2R2，用于以鸡毒支原体S6株基因组DNA为模板的PCR反应。
A pair of degenerate oligonucleotide primers named L2R2were synthesized according to conserved regions of the cytadhesin proteins from M. pneumonias. MG-S6DNA were used as model in L2R2 primered PCR.
应用寡核苷酸诱导的定点突变和PCR技术对人脑源性神经营养因子基因进行突变，并完成了测序鉴定。
Human brain derived neurotrophic factor gene was used as template for oligonucleotide based site directed mutagenesis and PCR.
研究Bcl - 2反义寡核苷酸联合照射对肺癌细胞的抑制作用。
To study the inhibitory effect of bcl-2 antisense oligonucleotide (ASODN) combined with radiation on lung carcinoma cells NCI-H446.
研究Bcl - 2反义寡核苷酸联合照射对肺癌细胞的抑制作用。
To study the inhibitory effect of bcl-2 antisense oligonucleotide (ASODN) combined with radiation on lung carcinoma cells NCI-H446.
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